| http://purl.uniprot.org/citations/33393489 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33393489 | http://www.w3.org/2000/01/rdf-schema#comment | "Fibrosis is a macrophage-driven process of uncontrolled extracellular matrix accumulation. Neuronal guidance proteins such as netrin-1 promote inflammatory scarring. We found that macrophage-derived netrin-1 stimulates fibrosis through its neuronal guidance functions. In mice, fibrosis due to inhaled bleomycin engendered netrin-1-expressing macrophages and fibroblasts, remodeled adrenergic nerves, and augmented noradrenaline. Cell-specific knockout mice showed that collagen accumulation, fibrotic histology, and nerve-associated endpoints required netrin-1 of macrophage but not fibroblast origin. Adrenergic denervation; haploinsufficiency of netrin-1's receptor, deleted in colorectal carcinoma; and therapeutic α1 adrenoreceptor antagonism improved collagen content and histology. An idiopathic pulmonary fibrosis (IPF) lung microarray data set showed increased netrin-1 expression. IPF lung tissues were enriched for netrin-1+ macrophages and noradrenaline. A longitudinal IPF cohort showed improved survival in patients prescribed α1 adrenoreceptor blockade. This work showed that macrophages stimulate lung fibrosis via netrin-1-driven adrenergic processes and introduced α1 blockers as a potentially new fibrotic therapy."xsd:string |
| http://purl.uniprot.org/citations/33393489 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci136542"xsd:string |
| http://purl.uniprot.org/citations/33393489 | http://purl.uniprot.org/core/author | "Gao R."xsd:string |
| http://purl.uniprot.org/citations/33393489 | http://purl.uniprot.org/core/author | "Peng X."xsd:string |
| http://purl.uniprot.org/citations/33393489 | http://purl.uniprot.org/core/author | "Sun H."xsd:string |
| http://purl.uniprot.org/citations/33393489 | http://purl.uniprot.org/core/author | "Eltzschig H.K."xsd:string |
| http://purl.uniprot.org/citations/33393489 | http://purl.uniprot.org/core/author | "Kaminski N."xsd:string |
| http://purl.uniprot.org/citations/33393489 | http://purl.uniprot.org/core/author | "Perry C."xsd:string |
| http://purl.uniprot.org/citations/33393489 | http://purl.uniprot.org/core/author | "Walia A."xsd:string |
| http://purl.uniprot.org/citations/33393489 | http://purl.uniprot.org/core/author | "Homer R.J."xsd:string |
| http://purl.uniprot.org/citations/33393489 | http://purl.uniprot.org/core/author | "Moore M.W."xsd:string |
| http://purl.uniprot.org/citations/33393489 | http://purl.uniprot.org/core/author | "Ishikawa G."xsd:string |
| http://purl.uniprot.org/citations/33393489 | http://purl.uniprot.org/core/author | "Herzog E.L."xsd:string |
| http://purl.uniprot.org/citations/33393489 | http://purl.uniprot.org/core/author | "Black K.E."xsd:string |
| http://purl.uniprot.org/citations/33393489 | http://purl.uniprot.org/core/author | "Hariri L.P."xsd:string |
| http://purl.uniprot.org/citations/33393489 | http://purl.uniprot.org/core/author | "Reeves B.C."xsd:string |
| http://purl.uniprot.org/citations/33393489 | http://purl.uniprot.org/core/author | "Ryu C."xsd:string |
| http://purl.uniprot.org/citations/33393489 | http://purl.uniprot.org/core/author | "Gulati M."xsd:string |
| http://purl.uniprot.org/citations/33393489 | http://purl.uniprot.org/core/author | "Gomez J.L."xsd:string |
| http://purl.uniprot.org/citations/33393489 | http://purl.uniprot.org/core/author | "Greif D.M."xsd:string |
| http://purl.uniprot.org/citations/33393489 | http://purl.uniprot.org/core/author | "Ntokou A."xsd:string |
| http://purl.uniprot.org/citations/33393489 | http://purl.uniprot.org/core/author | "Neumark N."xsd:string |
| http://purl.uniprot.org/citations/33393489 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33393489 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |