| http://purl.uniprot.org/citations/33397806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33397806 | http://www.w3.org/2000/01/rdf-schema#comment | "Physiological functioning and homeostasis of the brain rely on finely tuned synaptic transmission, which involves nanoscale alignment between presynaptic neurotransmitter-release machinery and postsynaptic receptors. However, the molecular identity and physiological significance of transsynaptic nanoalignment remain incompletely understood. Here, we report that epilepsy gene products, a secreted protein LGI1 and its receptor ADAM22, govern transsynaptic nanoalignment to prevent epilepsy. We found that LGI1-ADAM22 instructs PSD-95 family membrane-associated guanylate kinases (MAGUKs) to organize transsynaptic protein networks, including NMDA/AMPA receptors, Kv1 channels, and LRRTM4-Neurexin adhesion molecules. Adam22ΔC5/ΔC5 knock-in mice devoid of the ADAM22-MAGUK interaction display lethal epilepsy of hippocampal origin, representing the mouse model for ADAM22-related epileptic encephalopathy. This model shows less-condensed PSD-95 nanodomains, disordered transsynaptic nanoalignment, and decreased excitatory synaptic transmission in the hippocampus. Strikingly, without ADAM22 binding, PSD-95 cannot potentiate AMPA receptor-mediated synaptic transmission. Furthermore, forced coexpression of ADAM22 and PSD-95 reconstitutes nano-condensates in nonneuronal cells. Collectively, this study reveals LGI1-ADAM22-MAGUK as an essential component of transsynaptic nanoarchitecture for precise synaptic transmission and epilepsy prevention."xsd:string |
| http://purl.uniprot.org/citations/33397806 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2022580118"xsd:string |
| http://purl.uniprot.org/citations/33397806 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/33397806 | http://purl.uniprot.org/core/author | "Goto T."xsd:string |
| http://purl.uniprot.org/citations/33397806 | http://purl.uniprot.org/core/author | "Sano H."xsd:string |
| http://purl.uniprot.org/citations/33397806 | http://purl.uniprot.org/core/author | "Fukai S."xsd:string |
| http://purl.uniprot.org/citations/33397806 | http://purl.uniprot.org/core/author | "Hirano Y."xsd:string |
| http://purl.uniprot.org/citations/33397806 | http://purl.uniprot.org/core/author | "Fukata M."xsd:string |
| http://purl.uniprot.org/citations/33397806 | http://purl.uniprot.org/core/author | "Fukata Y."xsd:string |
| http://purl.uniprot.org/citations/33397806 | http://purl.uniprot.org/core/author | "Nicoll R.A."xsd:string |
| http://purl.uniprot.org/citations/33397806 | http://purl.uniprot.org/core/author | "Yamagata A."xsd:string |
| http://purl.uniprot.org/citations/33397806 | http://purl.uniprot.org/core/author | "Nambu A."xsd:string |
| http://purl.uniprot.org/citations/33397806 | http://purl.uniprot.org/core/author | "Sanbo M."xsd:string |
| http://purl.uniprot.org/citations/33397806 | http://purl.uniprot.org/core/author | "Kornau H.C."xsd:string |
| http://purl.uniprot.org/citations/33397806 | http://purl.uniprot.org/core/author | "Hirabayashi M."xsd:string |
| http://purl.uniprot.org/citations/33397806 | http://purl.uniprot.org/core/author | "Pruss H."xsd:string |
| http://purl.uniprot.org/citations/33397806 | http://purl.uniprot.org/core/author | "Chiken S."xsd:string |
| http://purl.uniprot.org/citations/33397806 | http://purl.uniprot.org/core/author | "Inahashi H."xsd:string |
| http://purl.uniprot.org/citations/33397806 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33397806 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/33397806 | http://purl.uniprot.org/core/pages | "e2022580118"xsd:string |
| http://purl.uniprot.org/citations/33397806 | http://purl.uniprot.org/core/title | "LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention."xsd:string |
| http://purl.uniprot.org/citations/33397806 | http://purl.uniprot.org/core/volume | "118"xsd:string |
| http://purl.uniprot.org/citations/33397806 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33397806 |