| http://purl.uniprot.org/citations/33398170 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33398170 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33398170 | http://www.w3.org/2000/01/rdf-schema#comment | "Proteome integrity depends on the ubiquitin-proteasome system to degrade unwanted or abnormal proteins. In addition to the N-degrons, C-terminal residues of proteins can also serve as degradation signals (C-degrons) that are recognized by specific cullin-RING ubiquitin ligases (CRLs) for proteasomal degradation. FEM1C is a CRL2 substrate receptor that targets the C-terminal arginine degron (Arg/C-degron), but the molecular mechanism of substrate recognition remains largely elusive. Here, we present crystal structures of FEM1C in complex with Arg/C-degron and show that FEM1C utilizes a semi-open binding pocket to capture the C-terminal arginine and that the extreme C-terminal arginine is the major structural determinant in recognition by FEM1C. Together with biochemical and mutagenesis studies, we provide a framework for understanding molecular recognition of the Arg/C-degron by the FEM family of proteins."xsd:string |
| http://purl.uniprot.org/citations/33398170 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41589-020-00703-4"xsd:string |
| http://purl.uniprot.org/citations/33398170 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41589-020-00703-4"xsd:string |
| http://purl.uniprot.org/citations/33398170 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/33398170 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/33398170 | http://purl.uniprot.org/core/author | "Mi W."xsd:string |
| http://purl.uniprot.org/citations/33398170 | http://purl.uniprot.org/core/author | "Mi W."xsd:string |
| http://purl.uniprot.org/citations/33398170 | http://purl.uniprot.org/core/author | "Song L."xsd:string |
| http://purl.uniprot.org/citations/33398170 | http://purl.uniprot.org/core/author | "Song L."xsd:string |
| http://purl.uniprot.org/citations/33398170 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/33398170 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/33398170 | http://purl.uniprot.org/core/author | "Yan X."xsd:string |
| http://purl.uniprot.org/citations/33398170 | http://purl.uniprot.org/core/author | "Yan X."xsd:string |
| http://purl.uniprot.org/citations/33398170 | http://purl.uniprot.org/core/author | "Zhou M."xsd:string |
| http://purl.uniprot.org/citations/33398170 | http://purl.uniprot.org/core/author | "Zhou M."xsd:string |
| http://purl.uniprot.org/citations/33398170 | http://purl.uniprot.org/core/author | "Min J."xsd:string |
| http://purl.uniprot.org/citations/33398170 | http://purl.uniprot.org/core/author | "Min J."xsd:string |
| http://purl.uniprot.org/citations/33398170 | http://purl.uniprot.org/core/author | "Dong C."xsd:string |
| http://purl.uniprot.org/citations/33398170 | http://purl.uniprot.org/core/author | "Dong C."xsd:string |
| http://purl.uniprot.org/citations/33398170 | http://purl.uniprot.org/core/author | "Li Y.'"xsd:string |
| http://purl.uniprot.org/citations/33398170 | http://purl.uniprot.org/core/author | "Li Y.'"xsd:string |
| http://purl.uniprot.org/citations/33398170 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33398170 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |