| http://purl.uniprot.org/citations/33406416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33406416 | http://www.w3.org/2000/01/rdf-schema#comment | "Gut microbiota have been shown to promote oogenesis and fecundity, but the mechanistic basis of remote influence on oogenesis remained unknown. Here, we report a systemic mechanism of influence mediated by bacterial-derived supply of mitochondrial coenzymes. Removal of microbiota decreased mitochondrial activity and ATP levels in the whole-body and ovary, resulting in repressed oogenesis. Similar repression was caused by RNA-based knockdown of mitochondrial function in ovarian follicle cells. Reduced mitochondrial function in germ-free (GF) females was reversed by bacterial recolonization or supplementation of riboflavin, a precursor of FAD and FMN. Metabolomics analysis of GF females revealed a decrease in oxidative phosphorylation and FAD levels and an increase in metabolites that are degraded by FAD-dependent enzymes (e.g., amino and fatty acids). Riboflavin supplementation opposed this effect, elevating mitochondrial function, ATP, and oogenesis. These findings uncover a bacterial-mitochondrial axis of influence, linking gut bacteria with systemic regulation of host energy and reproduction."xsd:string |
| http://purl.uniprot.org/citations/33406416 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2020.108583"xsd:string |
| http://purl.uniprot.org/citations/33406416 | http://purl.uniprot.org/core/author | "Brandis A."xsd:string |
| http://purl.uniprot.org/citations/33406416 | http://purl.uniprot.org/core/author | "Mehlman T."xsd:string |
| http://purl.uniprot.org/citations/33406416 | http://purl.uniprot.org/core/author | "Adamski J."xsd:string |
| http://purl.uniprot.org/citations/33406416 | http://purl.uniprot.org/core/author | "Malitsky S."xsd:string |
| http://purl.uniprot.org/citations/33406416 | http://purl.uniprot.org/core/author | "Itkin M."xsd:string |
| http://purl.uniprot.org/citations/33406416 | http://purl.uniprot.org/core/author | "Gnainsky Y."xsd:string |
| http://purl.uniprot.org/citations/33406416 | http://purl.uniprot.org/core/author | "Soen Y."xsd:string |
| http://purl.uniprot.org/citations/33406416 | http://purl.uniprot.org/core/author | "Elgart M."xsd:string |
| http://purl.uniprot.org/citations/33406416 | http://purl.uniprot.org/core/author | "Omri E."xsd:string |
| http://purl.uniprot.org/citations/33406416 | http://purl.uniprot.org/core/author | "Zfanya N."xsd:string |
| http://purl.uniprot.org/citations/33406416 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33406416 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/33406416 | http://purl.uniprot.org/core/pages | "108583"xsd:string |
| http://purl.uniprot.org/citations/33406416 | http://purl.uniprot.org/core/title | "Systemic Regulation of Host Energy and Oogenesis by Microbiome-Derived Mitochondrial Coenzymes."xsd:string |
| http://purl.uniprot.org/citations/33406416 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/33406416 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33406416 |
| http://purl.uniprot.org/citations/33406416 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33406416 |
| http://purl.uniprot.org/uniprot/#_D0Z747-mappedCitation-33406416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33406416 |
| http://purl.uniprot.org/uniprot/#_E2QCQ3-mappedCitation-33406416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33406416 |
| http://purl.uniprot.org/uniprot/#_G4LTX1-mappedCitation-33406416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33406416 |
| http://purl.uniprot.org/uniprot/#_P00850-mappedCitation-33406416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33406416 |
| http://purl.uniprot.org/uniprot/#_P18929-mappedCitation-33406416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33406416 |