| http://purl.uniprot.org/citations/33408417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33408417 | http://www.w3.org/2000/01/rdf-schema#comment | "Astrocytes are glial cells that are abundant in the central nervous system (CNS) and that have important homeostatic and disease-promoting functions1. However, little is known about the homeostatic anti-inflammatory activities of astrocytes and their regulation. Here, using high-throughput flow cytometry screening, single-cell RNA sequencing and CRISPR-Cas9-based cell-specific in vivo genetic perturbations in mice, we identify a subset of astrocytes that expresses the lysosomal protein LAMP12 and the death receptor ligand TRAIL3. LAMP1+TRAIL+ astrocytes limit inflammation in the CNS by inducing T cell apoptosis through TRAIL-DR5 signalling. In homeostatic conditions, the expression of TRAIL in astrocytes is driven by interferon-γ (IFNγ) produced by meningeal natural killer (NK) cells, in which IFNγ expression is modulated by the gut microbiome. TRAIL expression in astrocytes is repressed by molecules produced by T cells and microglia in the context of inflammation. Altogether, we show that LAMP1+TRAIL+ astrocytes limit CNS inflammation by inducing T cell apoptosis, and that this astrocyte subset is maintained by meningeal IFNγ+ NK cells that are licensed by the microbiome."xsd:string |
| http://purl.uniprot.org/citations/33408417 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41586-020-03116-4"xsd:string |
| http://purl.uniprot.org/citations/33408417 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/33408417 | http://purl.uniprot.org/core/author | "Prat A."xsd:string |
| http://purl.uniprot.org/citations/33408417 | http://purl.uniprot.org/core/author | "Becher B."xsd:string |
| http://purl.uniprot.org/citations/33408417 | http://purl.uniprot.org/core/author | "Chiu I.M."xsd:string |
| http://purl.uniprot.org/citations/33408417 | http://purl.uniprot.org/core/author | "Quintana F.J."xsd:string |
| http://purl.uniprot.org/citations/33408417 | http://purl.uniprot.org/core/author | "Wheeler M.A."xsd:string |
| http://purl.uniprot.org/citations/33408417 | http://purl.uniprot.org/core/author | "Gutierrez-Vazquez C."xsd:string |
| http://purl.uniprot.org/citations/33408417 | http://purl.uniprot.org/core/author | "Rosene D.L."xsd:string |
| http://purl.uniprot.org/citations/33408417 | http://purl.uniprot.org/core/author | "Sanmarco L.M."xsd:string |
| http://purl.uniprot.org/citations/33408417 | http://purl.uniprot.org/core/author | "Scalisi G."xsd:string |
| http://purl.uniprot.org/citations/33408417 | http://purl.uniprot.org/core/author | "Zandee S.E.J."xsd:string |
| http://purl.uniprot.org/citations/33408417 | http://purl.uniprot.org/core/author | "Pinho-Ribeiro F.A."xsd:string |
| http://purl.uniprot.org/citations/33408417 | http://purl.uniprot.org/core/author | "Giovannoni F."xsd:string |
| http://purl.uniprot.org/citations/33408417 | http://purl.uniprot.org/core/author | "Linnerbauer M."xsd:string |
| http://purl.uniprot.org/citations/33408417 | http://purl.uniprot.org/core/author | "Alsuwailm M."xsd:string |
| http://purl.uniprot.org/citations/33408417 | http://purl.uniprot.org/core/author | "Batterman K.V."xsd:string |
| http://purl.uniprot.org/citations/33408417 | http://purl.uniprot.org/core/author | "Heck E.S."xsd:string |
| http://purl.uniprot.org/citations/33408417 | http://purl.uniprot.org/core/author | "Polonio C.M."xsd:string |
| http://purl.uniprot.org/citations/33408417 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33408417 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/33408417 | http://purl.uniprot.org/core/pages | "473-479"xsd:string |
| http://purl.uniprot.org/citations/33408417 | http://purl.uniprot.org/core/title | "Gut-licensed IFNgammapisup>+pi/sup> NK cells drive LAMP1pisup>+pi/sup>TRAILpisup>+pi/sup> anti-inflammatory astrocytes."xsd:string |