| http://purl.uniprot.org/citations/33410748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33410748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33410748 | http://www.w3.org/2000/01/rdf-schema#comment | "The NLRP1 inflammasome is a multiprotein complex that is a potent activator of inflammation. Mouse NLRP1B can be activated through proteolytic cleavage by the bacterial Lethal Toxin (LeTx) protease, resulting in degradation of the N-terminal domains of NLRP1B and liberation of the bioactive C-terminal domain, which includes the caspase activation and recruitment domain (CARD). However, natural pathogen-derived effectors that can activate human NLRP1 have remained unknown. Here, we use an evolutionary model to identify several proteases from diverse picornaviruses that cleave human NLRP1 within a rapidly evolving region of the protein, leading to host-specific and virus-specific activation of the NLRP1 inflammasome. Our work demonstrates that NLRP1 acts as a 'tripwire' to recognize the enzymatic function of a wide range of viral proteases and suggests that host mimicry of viral polyprotein cleavage sites can be an evolutionary strategy to activate a robust inflammatory immune response."xsd:string |
| http://purl.uniprot.org/citations/33410748 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.60609"xsd:string |
| http://purl.uniprot.org/citations/33410748 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.60609"xsd:string |
| http://purl.uniprot.org/citations/33410748 | http://purl.uniprot.org/core/author | "Agarwal R."xsd:string |
| http://purl.uniprot.org/citations/33410748 | http://purl.uniprot.org/core/author | "Agarwal R."xsd:string |
| http://purl.uniprot.org/citations/33410748 | http://purl.uniprot.org/core/author | "Beierschmitt C."xsd:string |
| http://purl.uniprot.org/citations/33410748 | http://purl.uniprot.org/core/author | "Beierschmitt C."xsd:string |
| http://purl.uniprot.org/citations/33410748 | http://purl.uniprot.org/core/author | "Daugherty M.D."xsd:string |
| http://purl.uniprot.org/citations/33410748 | http://purl.uniprot.org/core/author | "Daugherty M.D."xsd:string |
| http://purl.uniprot.org/citations/33410748 | http://purl.uniprot.org/core/author | "Mitchell P.S."xsd:string |
| http://purl.uniprot.org/citations/33410748 | http://purl.uniprot.org/core/author | "Mitchell P.S."xsd:string |
| http://purl.uniprot.org/citations/33410748 | http://purl.uniprot.org/core/author | "Ryan A.P."xsd:string |
| http://purl.uniprot.org/citations/33410748 | http://purl.uniprot.org/core/author | "Ryan A.P."xsd:string |
| http://purl.uniprot.org/citations/33410748 | http://purl.uniprot.org/core/author | "Tsu B.V."xsd:string |
| http://purl.uniprot.org/citations/33410748 | http://purl.uniprot.org/core/author | "Tsu B.V."xsd:string |
| http://purl.uniprot.org/citations/33410748 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33410748 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33410748 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/33410748 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/33410748 | http://purl.uniprot.org/core/title | "Diverse viral proteases activate the NLRP1 inflammasome."xsd:string |
| http://purl.uniprot.org/citations/33410748 | http://purl.uniprot.org/core/title | "Diverse viral proteases activate the NLRP1 inflammasome."xsd:string |
| http://purl.uniprot.org/citations/33410748 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/33410748 | http://purl.uniprot.org/core/volume | "10"xsd:string |