Results

RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/33413127http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/33413127http://www.w3.org/2000/01/rdf-schema#comment"

Background

Infective endocarditis (IE) is a life-threatening disease whose prognosis is often difficult to predict based on clinical data. Biomarkers have been shown to favorably affect disease management in a number of cardiac disorders. Aims of this retrospective study were to assess the prognostic role of procalcitonin (PCT), pro-adrenomedullin (pro-ADM) and copeptin in IE and their relation with disease characteristics and the traditional biomarker C-reactive protein (CRP).

Methods

We studied 196 patients with definite IE. Clinical, laboratory and echocardiography parameters were analyzed, with a focus on co-morbidities. PCT, pro-ADM and copeptin were measured on stored plasma samples obtained on admission during the acute phase of the disease.

Results

Pro-ADM and copeptin were significantly higher in older patients and associated with prior chronic kidney disease. Pro-ADM was an independent predictor of hospital mortality (OR 3.29 [95%C.I. 1.04-11.5]; p = 0.042) whilst copeptin independently predicted 1-year mortality (OR 2.55 [95%C.I. 1.18-5.54]; p = 0.017). A high PCT value was strictly tied with S. aureus etiology (p = 0.001). CRP was the only biomarker associated with embolic events (p = 0.003).

Conclusions

Different biomarkers correlate with distinct IE outcomes. Pro-ADM and copeptin may signal a worse prognosis of IE on admission to the hospital and could be used to identify patients who need more aggressive treatment. CRP remains a low-cost marker of embolic risk. A high PCT value should suggest S. aureus etiology."xsd:string
http://purl.uniprot.org/citations/33413127http://purl.org/dc/terms/identifier"doi:10.1186/s12879-020-05655-7"xsd:string
http://purl.uniprot.org/citations/33413127http://purl.uniprot.org/core/author"Leonardi S."xsd:string
http://purl.uniprot.org/citations/33413127http://purl.uniprot.org/core/author"Zampino R."xsd:string
http://purl.uniprot.org/citations/33413127http://purl.uniprot.org/core/author"Durante-Mangoni E."xsd:string
http://purl.uniprot.org/citations/33413127http://purl.uniprot.org/core/author"Atripaldi L."xsd:string
http://purl.uniprot.org/citations/33413127http://purl.uniprot.org/core/author"Andini R."xsd:string
http://purl.uniprot.org/citations/33413127http://purl.uniprot.org/core/author"Iossa D."xsd:string
http://purl.uniprot.org/citations/33413127http://purl.uniprot.org/core/author"Molaro R."xsd:string
http://purl.uniprot.org/citations/33413127http://purl.uniprot.org/core/author"Bertolino L."xsd:string
http://purl.uniprot.org/citations/33413127http://purl.uniprot.org/core/author"Fabrazzo O."xsd:string
http://purl.uniprot.org/citations/33413127http://purl.uniprot.org/core/author"Ursi M.P."xsd:string
http://purl.uniprot.org/citations/33413127http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/33413127http://purl.uniprot.org/core/name"BMC Infect Dis"xsd:string
http://purl.uniprot.org/citations/33413127http://purl.uniprot.org/core/pages"23"xsd:string
http://purl.uniprot.org/citations/33413127http://purl.uniprot.org/core/title"Prognostic value of pro-adrenomedullin and copeptin in acute infective endocarditis."xsd:string
http://purl.uniprot.org/citations/33413127http://purl.uniprot.org/core/volume"21"xsd:string
http://purl.uniprot.org/citations/33413127http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/33413127
http://purl.uniprot.org/citations/33413127http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/33413127
http://purl.uniprot.org/uniprot/#_P35318-mappedCitation-33413127http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/33413127
http://purl.uniprot.org/uniprot/P35318http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/33413127