Results

RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/33417302http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/33417302http://www.w3.org/2000/01/rdf-schema#comment"

Aims

Cardiac autonomic neuropathy (CAN) is a serious complication of diabetes and is associated with adipokines. The C1q tumor necrosis factor-related protein 9 (CTRP9) is a newly discovered adipokine. This study aimed to evaluate the association of serum CTRP9 levels with the prevalence and severity of CAN in patients with type 2 diabetes mellitus.

Materials and methods

We enrolled 262 patients (aged ≥18 years) with type 2 diabetes mellitus into this study. Standard cardiovascular autonomic reflex tests (CARTs) were used to assess CAN and patients were divided into three groups accordingly: a non-CAN group, an early CAN group, and a definite CAN group. Serum CTRP9 levels were measured by enzyme-linked immunosorbent assay, and the tertiles were calculated.

Results

Serum CTRP9 levels decreased significantly in the early CAN and definite CAN groups (P < 0.05). The percentage of definite CAN was the highest at the minimum tertile of serum CTRP9 level (T1; P < 0.05). Additionally, serum CTRP9 levels were negatively correlated with age, DM duration, hemoglobin A1c (HbA1c), and fasting plasma glucose (FPG) while positively correlated with high-density lipoprotein cholesterol (HDL; P < 0.05). The level of CTRP9 was also significantly associated with the four indexes of CARTs (P < 0.05). Furthermore, CTRP9 was a protective factor for definite CAN (P < 0.05). Compared with the maximum tertile (T3) of the serum CTRP9 levels, a decreased level of serum CTRP9 in T1 significantly increased the prevalence ratio of definite CAN in patients with type 2 diabetes mellitus (P < 0.05).

Conclusion

Serum CTRP9 levels were independently associated with definite CAN. CTRP9 represents a reliable biomarker for exploring CAN in patients with type 2 diabetes mellitus."xsd:string
http://purl.uniprot.org/citations/33417302http://purl.org/dc/terms/identifier"doi:10.1111/jdi.13495"xsd:string
http://purl.uniprot.org/citations/33417302http://purl.uniprot.org/core/author"Chen Y."xsd:string
http://purl.uniprot.org/citations/33417302http://purl.uniprot.org/core/author"Lv Y."xsd:string
http://purl.uniprot.org/citations/33417302http://purl.uniprot.org/core/author"Ma Y."xsd:string
http://purl.uniprot.org/citations/33417302http://purl.uniprot.org/core/author"Shi X."xsd:string
http://purl.uniprot.org/citations/33417302http://purl.uniprot.org/core/author"Yang J."xsd:string
http://purl.uniprot.org/citations/33417302http://purl.uniprot.org/core/author"Wang X."xsd:string
http://purl.uniprot.org/citations/33417302http://purl.uniprot.org/core/author"Zhao D."xsd:string
http://purl.uniprot.org/citations/33417302http://purl.uniprot.org/core/author"Yuan H."xsd:string
http://purl.uniprot.org/citations/33417302http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/33417302http://purl.uniprot.org/core/name"J Diabetes Investig"xsd:string
http://purl.uniprot.org/citations/33417302http://purl.uniprot.org/core/pages"1442-1451"xsd:string
http://purl.uniprot.org/citations/33417302http://purl.uniprot.org/core/title"Association of serum CTRP9 levels with cardiac autonomic neuropathy in patients with type 2 diabetes mellitus."xsd:string
http://purl.uniprot.org/citations/33417302http://purl.uniprot.org/core/volume"12"xsd:string
http://purl.uniprot.org/citations/33417302http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/33417302
http://purl.uniprot.org/citations/33417302http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/33417302
http://purl.uniprot.org/uniprot/#_P0C862-mappedCitation-33417302http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/33417302
http://purl.uniprot.org/uniprot/#_A0A3B0J259-mappedCitation-33417302http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/33417302
http://purl.uniprot.org/uniprot/A0A3B0J259http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/33417302
http://purl.uniprot.org/uniprot/P0C862http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/33417302