| http://purl.uniprot.org/citations/33417895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33417895 | http://www.w3.org/2000/01/rdf-schema#comment | "N6-methyladenosine (m6A) mRNA methylation has been shown to regulate obesity and type 2 diabetes. However, whether METTL3, the key methyltransferase for m6A mRNA methylation, regulates β-cell failure in diabetes has not been fully explored. Here, we show that METTL3 is downregulated under the inflammatory and oxidative stress conditions, and islet β-cell-specific deletion of Mettl3 induces β-cell failure and hyperglycemia, which is likely due to decreased m6A modification and reduced expression of insulin secretion-related genes. Overall, METTL3 might be a potential drug target for the treatment of β-cell failure in diabetes."xsd:string |
| http://purl.uniprot.org/citations/33417895 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.metabol.2021.154702"xsd:string |
| http://purl.uniprot.org/citations/33417895 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/33417895 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/33417895 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/33417895 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/33417895 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/33417895 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33417895 | http://purl.uniprot.org/core/name | "Metabolism"xsd:string |
| http://purl.uniprot.org/citations/33417895 | http://purl.uniprot.org/core/pages | "154702"xsd:string |
| http://purl.uniprot.org/citations/33417895 | http://purl.uniprot.org/core/title | "METTL3 is required for maintaining beta-cell function."xsd:string |
| http://purl.uniprot.org/citations/33417895 | http://purl.uniprot.org/core/volume | "116"xsd:string |
| http://purl.uniprot.org/citations/33417895 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33417895 |
| http://purl.uniprot.org/citations/33417895 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33417895 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J041-mappedCitation-33417895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33417895 |
| http://purl.uniprot.org/uniprot/#_G3UXN3-mappedCitation-33417895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33417895 |
| http://purl.uniprot.org/uniprot/#_G3UXX7-mappedCitation-33417895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33417895 |
| http://purl.uniprot.org/uniprot/#_G3UY98-mappedCitation-33417895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33417895 |
| http://purl.uniprot.org/uniprot/#_G3UYB5-mappedCitation-33417895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33417895 |
| http://purl.uniprot.org/uniprot/#_G3UZP2-mappedCitation-33417895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33417895 |
| http://purl.uniprot.org/uniprot/#_G3UZP3-mappedCitation-33417895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33417895 |
| http://purl.uniprot.org/uniprot/#_G5E922-mappedCitation-33417895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33417895 |
| http://purl.uniprot.org/uniprot/#_G3UX68-mappedCitation-33417895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33417895 |
| http://purl.uniprot.org/uniprot/#_Q3U6J4-mappedCitation-33417895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33417895 |