| http://purl.uniprot.org/citations/33421364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33421364 | http://www.w3.org/2000/01/rdf-schema#comment | "Homologous recombination (HR) is essential for maintenance of genome integrity. Rad51 paralogs fulfill a conserved but undefined role in HR, and their mutations are associated with increased cancer risk in humans. Here, we use single-molecule imaging to reveal that the Saccharomyces cerevisiae Rad51 paralog complex Rad55-Rad57 promotes assembly of Rad51 recombinase filament through transient interactions, providing evidence that it acts like a classical molecular chaperone. Srs2 is an ATP-dependent anti-recombinase that downregulates HR by actively dismantling Rad51 filaments. Contrary to the current model, we find that Rad55-Rad57 does not physically block the movement of Srs2. Instead, Rad55-Rad57 promotes rapid re-assembly of Rad51 filaments after their disruption by Srs2. Our findings support a model in which Rad51 is in flux between free and single-stranded DNA (ssDNA)-bound states, the rate of which is controlled dynamically though the opposing actions of Rad55-Rad57 and Srs2."xsd:string |
| http://purl.uniprot.org/citations/33421364 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2020.12.019"xsd:string |
| http://purl.uniprot.org/citations/33421364 | http://purl.uniprot.org/core/author | "Sung P."xsd:string |
| http://purl.uniprot.org/citations/33421364 | http://purl.uniprot.org/core/author | "Lisby M."xsd:string |
| http://purl.uniprot.org/citations/33421364 | http://purl.uniprot.org/core/author | "Greene E.C."xsd:string |
| http://purl.uniprot.org/citations/33421364 | http://purl.uniprot.org/core/author | "Kwon Y."xsd:string |
| http://purl.uniprot.org/citations/33421364 | http://purl.uniprot.org/core/author | "Roy U."xsd:string |
| http://purl.uniprot.org/citations/33421364 | http://purl.uniprot.org/core/author | "Marie L."xsd:string |
| http://purl.uniprot.org/citations/33421364 | http://purl.uniprot.org/core/author | "Symington L."xsd:string |
| http://purl.uniprot.org/citations/33421364 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33421364 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/33421364 | http://purl.uniprot.org/core/pages | "1043-1057.e8"xsd:string |
| http://purl.uniprot.org/citations/33421364 | http://purl.uniprot.org/core/title | "The Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination."xsd:string |
| http://purl.uniprot.org/citations/33421364 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/33421364 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33421364 |
| http://purl.uniprot.org/citations/33421364 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33421364 |
| http://purl.uniprot.org/uniprot/#_A0A8H8ULW3-mappedCitation-33421364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33421364 |
| http://purl.uniprot.org/uniprot/#_A0A8H8UMS6-mappedCitation-33421364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33421364 |
| http://purl.uniprot.org/uniprot/#_A0A8H8UMZ2-mappedCitation-33421364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33421364 |
| http://purl.uniprot.org/uniprot/#_P38953-mappedCitation-33421364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33421364 |
| http://purl.uniprot.org/uniprot/#_P25301-mappedCitation-33421364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33421364 |
| http://purl.uniprot.org/uniprot/#_P25454-mappedCitation-33421364 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33421364 |
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| http://purl.uniprot.org/uniprot/P25454 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33421364 |