| http://purl.uniprot.org/citations/33421564 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33421564 | http://www.w3.org/2000/01/rdf-schema#comment | "In Parkinson's disease, synucleinopathy is hypothesized to spread from the enteric nervous system, via the vagus nerve, to the central nervous system. Recent evidences collected in non-human primates challenge however the hypothesis of a transmission of α-synuclein (α-syn) pathology through the vagus nerve. Would the hypothesis whereby the bloodstream acts as a route for long-distance transmission of pathological α-syn hold true, an inter-individual transmission of synucleinopathy could occur via blood contact. Here, we used a parabiosis approach to join the circulatory systems of wild type and GFP transgenic C57BL/6 J mice, for which one of the partners parabiont received a stereotaxic intranigral injection of patient-derived α-syn aggregates. While the Lewy Body-receiving mice exhibited a loss of dopamine neurons and an increase in nigral S129 phosphorylated α-syn immunoreactivity, their parabiotic bloodstream-sharing partners did not show any trend for a lesion or change in S129 phosphorylated-α-syn levels. Altogether, our study suggests that, in the patient-derived α-synuclein aggregates-injected mouse model and within the selected time frame, the disease is not "transmitted" through the bloodstream."xsd:string |
| http://purl.uniprot.org/citations/33421564 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.nbd.2021.105255"xsd:string |
| http://purl.uniprot.org/citations/33421564 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/33421564 | http://purl.uniprot.org/core/author | "Qin C."xsd:string |
| http://purl.uniprot.org/citations/33421564 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/33421564 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/33421564 | http://purl.uniprot.org/core/author | "Yu X."xsd:string |
| http://purl.uniprot.org/citations/33421564 | http://purl.uniprot.org/core/author | "Ran G."xsd:string |
| http://purl.uniprot.org/citations/33421564 | http://purl.uniprot.org/core/author | "Bezard E."xsd:string |
| http://purl.uniprot.org/citations/33421564 | http://purl.uniprot.org/core/author | "Dovero S."xsd:string |
| http://purl.uniprot.org/citations/33421564 | http://purl.uniprot.org/core/author | "Dehay B."xsd:string |
| http://purl.uniprot.org/citations/33421564 | http://purl.uniprot.org/core/author | "Porras G."xsd:string |
| http://purl.uniprot.org/citations/33421564 | http://purl.uniprot.org/core/author | "Breger L.S."xsd:string |
| http://purl.uniprot.org/citations/33421564 | http://purl.uniprot.org/core/author | "Persillet M."xsd:string |
| http://purl.uniprot.org/citations/33421564 | http://purl.uniprot.org/core/author | "Xiuping S."xsd:string |
| http://purl.uniprot.org/citations/33421564 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33421564 | http://purl.uniprot.org/core/name | "Neurobiol Dis"xsd:string |
| http://purl.uniprot.org/citations/33421564 | http://purl.uniprot.org/core/pages | "105255"xsd:string |
| http://purl.uniprot.org/citations/33421564 | http://purl.uniprot.org/core/title | "Evaluation of blood flow as a route for propagation in experimental synucleinopathy."xsd:string |
| http://purl.uniprot.org/citations/33421564 | http://purl.uniprot.org/core/volume | "150"xsd:string |
| http://purl.uniprot.org/citations/33421564 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33421564 |
| http://purl.uniprot.org/citations/33421564 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33421564 |
| http://purl.uniprot.org/uniprot/#_O55042-mappedCitation-33421564 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33421564 |
| http://purl.uniprot.org/uniprot/O55042 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33421564 |