| http://purl.uniprot.org/citations/33423291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33423291 | http://www.w3.org/2000/01/rdf-schema#comment | "Interferon regulatory factor 5 (IRF5) is a master regulator of macrophage phenotype and a key transcription factor involved in expression of proinflammatory cytokine responses to microbial and viral infection. Here, we show that IRF5 controls cellular and metabolic responses. By integrating ChIP sequencing (ChIP-Seq) and assay for transposase-accessible chromatin using sequencing (ATAC)-seq data sets, we found that IRF5 directly regulates metabolic genes such as hexokinase-2 (Hk2). The interaction of IRF5 and metabolic genes had a functional consequence, as Irf5-/- airway macrophages but not bone marrow-derived macrophages (BMDMs) were characterized by a quiescent metabolic phenotype at baseline and had reduced ability to utilize oxidative phosphorylation after Toll-like receptor (TLR)-3 activation, in comparison to controls, ex vivo. In a murine model of influenza infection, IRF5 deficiency had no effect on viral load in comparison to wild-type controls but controlled metabolic responses to viral infection, as IRF5 deficiency led to reduced expression of Sirt6 and Hk2. Together, our data indicate that IRF5 is a key component of AM metabolic responses following influenza infection and TLR-3 activation."xsd:string |
| http://purl.uniprot.org/citations/33423291 | http://purl.org/dc/terms/identifier | "doi:10.1111/cei.13573"xsd:string |
| http://purl.uniprot.org/citations/33423291 | http://purl.uniprot.org/core/author | "Lloyd C.M."xsd:string |
| http://purl.uniprot.org/citations/33423291 | http://purl.uniprot.org/core/author | "Iwasaki J."xsd:string |
| http://purl.uniprot.org/citations/33423291 | http://purl.uniprot.org/core/author | "Udalova I.A."xsd:string |
| http://purl.uniprot.org/citations/33423291 | http://purl.uniprot.org/core/author | "McErlean P."xsd:string |
| http://purl.uniprot.org/citations/33423291 | http://purl.uniprot.org/core/author | "Byrne A.J."xsd:string |
| http://purl.uniprot.org/citations/33423291 | http://purl.uniprot.org/core/author | "Ghai P."xsd:string |
| http://purl.uniprot.org/citations/33423291 | http://purl.uniprot.org/core/author | "Khoyratty T.E."xsd:string |
| http://purl.uniprot.org/citations/33423291 | http://purl.uniprot.org/core/author | "Albers G.J."xsd:string |
| http://purl.uniprot.org/citations/33423291 | http://purl.uniprot.org/core/author | "Ogger P.P."xsd:string |
| http://purl.uniprot.org/citations/33423291 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33423291 | http://purl.uniprot.org/core/name | "Clin Exp Immunol"xsd:string |
| http://purl.uniprot.org/citations/33423291 | http://purl.uniprot.org/core/pages | "134-143"xsd:string |
| http://purl.uniprot.org/citations/33423291 | http://purl.uniprot.org/core/title | "IRF5 regulates airway macrophage metabolic responses."xsd:string |
| http://purl.uniprot.org/citations/33423291 | http://purl.uniprot.org/core/volume | "204"xsd:string |
| http://purl.uniprot.org/citations/33423291 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33423291 |
| http://purl.uniprot.org/citations/33423291 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33423291 |
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| http://purl.uniprot.org/uniprot/#_F6Z6C6-mappedCitation-33423291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33423291 |
| http://purl.uniprot.org/uniprot/#_Q3U169-mappedCitation-33423291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33423291 |
| http://purl.uniprot.org/uniprot/F6Z6C6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33423291 |
| http://purl.uniprot.org/uniprot/P56477 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33423291 |