| http://purl.uniprot.org/citations/33443146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33443146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33443146 | http://www.w3.org/2000/01/rdf-schema#comment | "The Ligand of Ate1 (Liat1) is a protein of unknown function that was originally discovered through its interaction with arginyl-tRNA protein transferase 1 (Ate1), a component of the Arg/N-degron pathway of protein degradation. Here, we characterized the functional domains of mouse Liat1 and found that its N-terminal half comprises an intrinsically disordered region (IDR) that facilitates its liquid-liquid phase separation (LLPS) in the nucleolus. Using bimolecular fluorescence complementation and immunocytochemistry, we found that Liat1 is targeted to the nucleolus by a low-complexity poly-K region within its IDR. We also found that the lysyl-hydroxylase activity of Jumonji Domain Containing 6 (Jmjd6) modifies Liat1, in a manner that requires the Liat1 poly-K region, and inhibits its nucleolar targeting and potential functions. In sum, this study reveals that Liat1 participates in nucleolar LLPS regulated by Jmjd6."xsd:string |
| http://purl.uniprot.org/citations/33443146 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2015887118"xsd:string |
| http://purl.uniprot.org/citations/33443146 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2015887118"xsd:string |
| http://purl.uniprot.org/citations/33443146 | http://purl.uniprot.org/core/author | "Alkhatatbeh M.A."xsd:string |
| http://purl.uniprot.org/citations/33443146 | http://purl.uniprot.org/core/author | "Alkhatatbeh M.A."xsd:string |
| http://purl.uniprot.org/citations/33443146 | http://purl.uniprot.org/core/author | "Arva A."xsd:string |
| http://purl.uniprot.org/citations/33443146 | http://purl.uniprot.org/core/author | "Arva A."xsd:string |
| http://purl.uniprot.org/citations/33443146 | http://purl.uniprot.org/core/author | "Brower C.S."xsd:string |
| http://purl.uniprot.org/citations/33443146 | http://purl.uniprot.org/core/author | "Brower C.S."xsd:string |
| http://purl.uniprot.org/citations/33443146 | http://purl.uniprot.org/core/author | "Duncan J."xsd:string |
| http://purl.uniprot.org/citations/33443146 | http://purl.uniprot.org/core/author | "Duncan J."xsd:string |
| http://purl.uniprot.org/citations/33443146 | http://purl.uniprot.org/core/author | "Kasu Y.A.T."xsd:string |
| http://purl.uniprot.org/citations/33443146 | http://purl.uniprot.org/core/author | "Kasu Y.A.T."xsd:string |
| http://purl.uniprot.org/citations/33443146 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33443146 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33443146 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/33443146 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/33443146 | http://purl.uniprot.org/core/title | "The Ligand of Ate1 is intrinsically disordered and participates in nucleolar phase separation regulated by Jumonji Domain Containing 6."xsd:string |
| http://purl.uniprot.org/citations/33443146 | http://purl.uniprot.org/core/title | "The Ligand of Ate1 is intrinsically disordered and participates in nucleolar phase separation regulated by Jumonji Domain Containing 6."xsd:string |
| http://purl.uniprot.org/citations/33443146 | http://purl.uniprot.org/core/volume | "118"xsd:string |
| http://purl.uniprot.org/citations/33443146 | http://purl.uniprot.org/core/volume | "118"xsd:string |
| http://purl.uniprot.org/citations/33443146 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33443146 |
| http://purl.uniprot.org/citations/33443146 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33443146 |