| http://purl.uniprot.org/citations/33446560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33446560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33446560 | http://www.w3.org/2000/01/rdf-schema#comment | "To initiate cotranscriptional splicing, RNA polymerase II (Pol II) recruits the U1 small nuclear ribonucleoprotein particle (U1 snRNP) to nascent precursor messenger RNA (pre-mRNA). Here, we report the cryo-electron microscopy structure of a mammalian transcribing Pol II-U1 snRNP complex. The structure reveals that Pol II and U1 snRNP interact directly. This interaction positions the pre-mRNA 5' splice site near the RNA exit site of Pol II. Extension of pre-mRNA retains the 5' splice site, leading to the formation of a "growing intron loop." Loop formation may facilitate scanning of nascent pre-mRNA for the 3' splice site, functional pairing of distant intron ends, and prespliceosome assembly. Our results provide a starting point for a mechanistic analysis of cotranscriptional spliceosome assembly and the biogenesis of mRNA isoforms by alternative splicing."xsd:string |
| http://purl.uniprot.org/citations/33446560 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.abf1870"xsd:string |
| http://purl.uniprot.org/citations/33446560 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.abf1870"xsd:string |
| http://purl.uniprot.org/citations/33446560 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/33446560 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/33446560 | http://purl.uniprot.org/core/author | "Cramer P."xsd:string |
| http://purl.uniprot.org/citations/33446560 | http://purl.uniprot.org/core/author | "Cramer P."xsd:string |
| http://purl.uniprot.org/citations/33446560 | http://purl.uniprot.org/core/author | "Luhrmann R."xsd:string |
| http://purl.uniprot.org/citations/33446560 | http://purl.uniprot.org/core/author | "Luhrmann R."xsd:string |
| http://purl.uniprot.org/citations/33446560 | http://purl.uniprot.org/core/author | "Aibara S."xsd:string |
| http://purl.uniprot.org/citations/33446560 | http://purl.uniprot.org/core/author | "Aibara S."xsd:string |
| http://purl.uniprot.org/citations/33446560 | http://purl.uniprot.org/core/author | "Agafonov D.E."xsd:string |
| http://purl.uniprot.org/citations/33446560 | http://purl.uniprot.org/core/author | "Agafonov D.E."xsd:string |
| http://purl.uniprot.org/citations/33446560 | http://purl.uniprot.org/core/author | "Vos S.M."xsd:string |
| http://purl.uniprot.org/citations/33446560 | http://purl.uniprot.org/core/author | "Vos S.M."xsd:string |
| http://purl.uniprot.org/citations/33446560 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33446560 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33446560 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/33446560 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/33446560 | http://purl.uniprot.org/core/pages | "305-309"xsd:string |
| http://purl.uniprot.org/citations/33446560 | http://purl.uniprot.org/core/pages | "305-309"xsd:string |
| http://purl.uniprot.org/citations/33446560 | http://purl.uniprot.org/core/title | "Structure of a transcribing RNA polymerase II-U1 snRNP complex."xsd:string |
| http://purl.uniprot.org/citations/33446560 | http://purl.uniprot.org/core/title | "Structure of a transcribing RNA polymerase II-U1 snRNP complex."xsd:string |