| http://purl.uniprot.org/citations/33460021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33460021 | http://www.w3.org/2000/01/rdf-schema#comment | "Psoriasis is a chronic inflammatory skin condition with regional and ethnic differences in its prevalence and clinical manifestations. Human leukocyte antigen (HLA)-Cw6 is the disease allele conferring the greatest risk to psoriasis, but its prevalence is lower in Asian individuals. Recent studies have found associations between HLA-Cw1 and some Asian populations with psoriasis, especially Southern Chinese. HLA-Cw6 was associated with type I early-onset psoriasis, guttate psoriasis, Koebner phenomenon, and better response to methotrexate, interleukin (IL)-12/23, IL-17, and IL-23 targeting drugs. In contrast, HLA-Cw1 positivity has been associated with erythrodermic psoriasis, pustular psoriasis, and the axial type of psoriatic arthritis. Furthermore, HLA-Cw1 was more frequently associated with high-need patients who did not respond to conventional therapies. No known trigger factor nor autoantigen has been identified for HLA-Cw1 positivity. However, HLA-Cw1 has been linked to some viral agents. For example, cytotoxic T lymphocytes recognize multiple cytomegalovirus pp65-derived epitopes presented by HLA alleles, including HLA-C*01:02. In addition, cytomegalovirus can lead to severe exacerbation of psoriatic skin disease. The proposed interaction between viral infection, HLA-Cw1, and psoriasis is through the killer cell immunoglobulin-like receptors of natural killer cells. Given the diverse nature of psoriasis pathogenesis and the difference in HLA-Cw prevalence in different racial groups, more studies are needed to confirm the role of HLA-Cw1 in psoriasis."xsd:string |
| http://purl.uniprot.org/citations/33460021 | http://purl.org/dc/terms/identifier | "doi:10.1007/s40257-020-00585-1"xsd:string |
| http://purl.uniprot.org/citations/33460021 | http://purl.uniprot.org/core/author | "Huang Y.W."xsd:string |
| http://purl.uniprot.org/citations/33460021 | http://purl.uniprot.org/core/author | "Tsai T.F."xsd:string |
| http://purl.uniprot.org/citations/33460021 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33460021 | http://purl.uniprot.org/core/name | "Am J Clin Dermatol"xsd:string |
| http://purl.uniprot.org/citations/33460021 | http://purl.uniprot.org/core/pages | "339-347"xsd:string |
| http://purl.uniprot.org/citations/33460021 | http://purl.uniprot.org/core/title | "HLA-Cw1 and Psoriasis."xsd:string |
| http://purl.uniprot.org/citations/33460021 | http://purl.uniprot.org/core/volume | "22"xsd:string |
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