| http://purl.uniprot.org/citations/33475455 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33475455 | http://www.w3.org/2000/01/rdf-schema#comment | "Accumulating evidence has reported the role of microRNA (miR) in retinoblastoma (RB). Therefore, the objective was to discuss how miR-362-3p exerted its function in RB cell progression via regulating ubiquitin-specific protease 2 (USP22) and lysine-specific histone demethylase 1 (LSD1). MiR-362-3p, USP22 and LSD1 expression in RB cells and tissues were tested. The biological functions of RB cells were detected via over-expressing miR-362-3p and down-regulating USP22. The target relationship of USP22 and miR-362-3p as well as the interaction of USP22 and LSD1 in RB was verified. Down-regulated miR-362-3p and up-regulated USP22 and LSD1 were demonstrated in RB tissues and cells. Restoring miR-362-3p and depleting USP22 attenuated invasion, proliferation and migration, and facilitated apoptosis of RB cells. USP22 was a target gene of miR-362-3p. USP22 deubiquitinated LSD1 in RB. It is revealed that miR-362-3p targets USP22 and then restrains invasion, proliferation and migration while promotes apoptosis of RB via reducing LSD1 modified by deubiquitination."xsd:string |
| http://purl.uniprot.org/citations/33475455 | http://purl.org/dc/terms/identifier | "doi:10.1080/15384101.2021.1874685"xsd:string |
| http://purl.uniprot.org/citations/33475455 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/33475455 | http://purl.uniprot.org/core/author | "Xu L."xsd:string |
| http://purl.uniprot.org/citations/33475455 | http://purl.uniprot.org/core/author | "Zheng G."xsd:string |
| http://purl.uniprot.org/citations/33475455 | http://purl.uniprot.org/core/author | "Rong J."xsd:string |
| http://purl.uniprot.org/citations/33475455 | http://purl.uniprot.org/core/author | "Lang L."xsd:string |
| http://purl.uniprot.org/citations/33475455 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33475455 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
| http://purl.uniprot.org/citations/33475455 | http://purl.uniprot.org/core/pages | "298-307"xsd:string |
| http://purl.uniprot.org/citations/33475455 | http://purl.uniprot.org/core/title | "microRNA-362-3p targets USP22 to retard retinoblastoma growth via reducing deubiquitination of LSD1."xsd:string |
| http://purl.uniprot.org/citations/33475455 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/33475455 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33475455 |
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| http://purl.uniprot.org/uniprot/A8K2R3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33475455 |