| http://purl.uniprot.org/citations/33477536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33477536 | http://www.w3.org/2000/01/rdf-schema#comment | "Patients diagnosed with basal-like breast cancer suffer from poor prognosis and limited treatment options. There is an urgent need to identify new targets that can benefit patients with basal-like and claudin-low (BL-CL) breast cancers. We screened fractions from our Marine Invertebrate Compound Library (MICL) to identify compounds that specifically target BL-CL breast cancers. We identified a previously unreported trisulfated sterol, i.e., topsentinol L trisulfate (TLT), which exhibited increased efficacy against BL-CL breast cancers relative to luminal/HER2+ breast cancer. Biochemical investigation of the effects of TLT on BL-CL cell lines revealed its ability to inhibit activation of AMP-activated protein kinase (AMPK) and checkpoint kinase 1 (CHK1) and to promote activation of p38. The importance of targeting AMPK and CHK1 in BL-CL cell lines was validated by treating a panel of breast cancer cell lines with known small molecule inhibitors of AMPK (dorsomorphin) and CHK1 (Ly2603618) and recording the increased effectiveness against BL-CL breast cancers as compared with luminal/HER2+ breast cancer. Finally, we generated a drug response gene-expression signature and projected it against a human tumor panel of 12 different cancer types to identify other cancer types sensitive to the compound. The TLT sensitivity gene-expression signature identified breast and bladder cancer as the most sensitive to TLT, while glioblastoma multiforme was the least sensitive."xsd:string |
| http://purl.uniprot.org/citations/33477536 | http://purl.org/dc/terms/identifier | "doi:10.3390/md19010041"xsd:string |
| http://purl.uniprot.org/citations/33477536 | http://purl.uniprot.org/core/author | "Lu Z."xsd:string |
| http://purl.uniprot.org/citations/33477536 | http://purl.uniprot.org/core/author | "Ireland C.M."xsd:string |
| http://purl.uniprot.org/citations/33477536 | http://purl.uniprot.org/core/author | "Van Wagoner R.M."xsd:string |
| http://purl.uniprot.org/citations/33477536 | http://purl.uniprot.org/core/author | "Harper M.K."xsd:string |
| http://purl.uniprot.org/citations/33477536 | http://purl.uniprot.org/core/author | "Smith T.E."xsd:string |
| http://purl.uniprot.org/citations/33477536 | http://purl.uniprot.org/core/author | "Bild A.H."xsd:string |
| http://purl.uniprot.org/citations/33477536 | http://purl.uniprot.org/core/author | "Moos P.J."xsd:string |
| http://purl.uniprot.org/citations/33477536 | http://purl.uniprot.org/core/author | "Piccolo S.R."xsd:string |
| http://purl.uniprot.org/citations/33477536 | http://purl.uniprot.org/core/author | "Venancio A.R."xsd:string |
| http://purl.uniprot.org/citations/33477536 | http://purl.uniprot.org/core/author | "El-Chaar N.N."xsd:string |
| http://purl.uniprot.org/citations/33477536 | http://purl.uniprot.org/core/author | "Shrestha G."xsd:string |
| http://purl.uniprot.org/citations/33477536 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33477536 | http://purl.uniprot.org/core/name | "Mar Drugs"xsd:string |
| http://purl.uniprot.org/citations/33477536 | http://purl.uniprot.org/core/pages | "41"xsd:string |
| http://purl.uniprot.org/citations/33477536 | http://purl.uniprot.org/core/title | "Topsentinol L Trisulfate, a Marine Natural Product That Targets Basal-like and Claudin-Low Breast Cancers."xsd:string |
| http://purl.uniprot.org/citations/33477536 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/33477536 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33477536 |
| http://purl.uniprot.org/citations/33477536 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33477536 |
| http://purl.uniprot.org/uniprot/#_O14757-mappedCitation-33477536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33477536 |
| http://purl.uniprot.org/uniprot/#_Q16539-mappedCitation-33477536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33477536 |
| http://purl.uniprot.org/uniprot/#_P54646-mappedCitation-33477536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33477536 |
| http://purl.uniprot.org/uniprot/O14757 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33477536 |