| http://purl.uniprot.org/citations/33477970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33477970 | http://www.w3.org/2000/01/rdf-schema#comment | "HDGF-related protein 2 (HRP-2) is a member of the Hepatoma-Derived Growth Factor-related protein family that harbors the structured PWWP and Integrase Binding Domain, known to associate with methylated histone tails or cellular and viral proteins, respectively. Interestingly, HRP-2 is a paralog of Lens Epithelium Derived Growth Factor p75 (LEDGF/p75), which is essential for MLL-rearranged (MLL-r) leukemia but dispensable for hematopoiesis. Sequel to these findings, we investigated the role of HRP-2 in hematopoiesis and MLL-r leukemia. Protein interactions were investigated by co-immunoprecipitation and validated using recombinant proteins in NMR. A systemic knockout mouse model was used to study normal hematopoiesis and MLL-ENL transformation upon the different HRP-2 genotypes. The role of HRP-2 in MLL-r and other leukemic, human cell lines was evaluated by lentiviral-mediated miRNA targeting HRP-2. We demonstrate that MLL and HRP-2 interact through a conserved interface, although this interaction proved less dependent on menin than the MLL-LEDGF/p75 interaction. The systemic HRP-2 knockout mice only revealed an increase in neutrophils in the peripheral blood, whereas the depletion of HRP-2 in leukemic cell lines and transformed primary murine cells resulted in reduced colony formation independently of MLL-rearrangements. In contrast, primary murine HRP-2 knockout cells were efficiently transformed by the MLL-ENL fusion, indicating that HRP-2, unlike LEDGF/p75, is dispensable for the transformation of MLL-ENL leukemogenesis but important for leukemic cell survival."xsd:string |
| http://purl.uniprot.org/citations/33477970 | http://purl.org/dc/terms/identifier | "doi:10.3390/cells10010192"xsd:string |
| http://purl.uniprot.org/citations/33477970 | http://purl.uniprot.org/core/author | "Veverka V."xsd:string |
| http://purl.uniprot.org/citations/33477970 | http://purl.uniprot.org/core/author | "Van Belle S."xsd:string |
| http://purl.uniprot.org/citations/33477970 | http://purl.uniprot.org/core/author | "Christ F."xsd:string |
| http://purl.uniprot.org/citations/33477970 | http://purl.uniprot.org/core/author | "De Rijck J."xsd:string |
| http://purl.uniprot.org/citations/33477970 | http://purl.uniprot.org/core/author | "Debyser Z."xsd:string |
| http://purl.uniprot.org/citations/33477970 | http://purl.uniprot.org/core/author | "Cermakova K."xsd:string |
| http://purl.uniprot.org/citations/33477970 | http://purl.uniprot.org/core/author | "El Ashkar S."xsd:string |
| http://purl.uniprot.org/citations/33477970 | http://purl.uniprot.org/core/author | "Goossens S."xsd:string |
| http://purl.uniprot.org/citations/33477970 | http://purl.uniprot.org/core/author | "Matthijssens F."xsd:string |
| http://purl.uniprot.org/citations/33477970 | http://purl.uniprot.org/core/author | "Canella A."xsd:string |
| http://purl.uniprot.org/citations/33477970 | http://purl.uniprot.org/core/author | "Van Vlierberghe P."xsd:string |
| http://purl.uniprot.org/citations/33477970 | http://purl.uniprot.org/core/author | "Hodges C.H."xsd:string |
| http://purl.uniprot.org/citations/33477970 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33477970 | http://purl.uniprot.org/core/name | "Cells"xsd:string |
| http://purl.uniprot.org/citations/33477970 | http://purl.uniprot.org/core/pages | "192"xsd:string |
| http://purl.uniprot.org/citations/33477970 | http://purl.uniprot.org/core/title | "Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival."xsd:string |
| http://purl.uniprot.org/citations/33477970 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/33477970 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33477970 |
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| http://purl.uniprot.org/uniprot/#_A0A1L1SQS9-mappedCitation-33477970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33477970 |
| http://purl.uniprot.org/uniprot/#_A2BI12-mappedCitation-33477970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33477970 |