| http://purl.uniprot.org/citations/33479228 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33479228 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic inflammation during many diseases is associated with bone loss. While interferons (IFNs) are often inhibitory to osteoclast formation, the complex role that IFN and interferon-stimulated genes (ISGs) play in osteoimmunology during inflammatory diseases is still poorly understood. We show that mice deficient in IFN signaling components including IFN alpha and beta receptor 1 (IFNAR1), interferon regulatory factor 1 (IRF1), IRF9, and STAT1 each have reduced bone density and increased osteoclastogenesis compared to wild type mice. The IFN-inducible guanylate-binding proteins (GBPs) on mouse chromosome 3 (GBP1, GBP2, GBP3, GBP5, GBP7) are required to negatively regulate age-associated bone loss and osteoclastogenesis. Mechanistically, GBP2 and GBP5 both negatively regulate in vitro osteoclast differentiation, and loss of GBP5, but not GBP2, results in greater age-associated bone loss in mice. Moreover, mice deficient in GBP5 or chromosome 3 GBPs have greater LPS-mediated inflammatory bone loss compared to wild type mice. Overall, we find that GBP5 contributes to restricting age-associated and inflammation-induced bone loss by negatively regulating osteoclastogenesis."xsd:string |
| http://purl.uniprot.org/citations/33479228 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-20807-8"xsd:string |
| http://purl.uniprot.org/citations/33479228 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/33479228 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/33479228 | http://purl.uniprot.org/core/author | "Kanneganti T.D."xsd:string |
| http://purl.uniprot.org/citations/33479228 | http://purl.uniprot.org/core/author | "Vogel P."xsd:string |
| http://purl.uniprot.org/citations/33479228 | http://purl.uniprot.org/core/author | "Malireddi R.K.S."xsd:string |
| http://purl.uniprot.org/citations/33479228 | http://purl.uniprot.org/core/author | "Place D.E."xsd:string |
| http://purl.uniprot.org/citations/33479228 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33479228 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/33479228 | http://purl.uniprot.org/core/pages | "496"xsd:string |
| http://purl.uniprot.org/citations/33479228 | http://purl.uniprot.org/core/title | "Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins."xsd:string |
| http://purl.uniprot.org/citations/33479228 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/33479228 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33479228 |
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