| http://purl.uniprot.org/citations/33493514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33493514 | http://www.w3.org/2000/01/rdf-schema#comment | "The Golgi apparatus (GA) is a cellular organelle that plays a critical role in the processing of proteins for secretion. Activation of G protein-coupled receptors at the plasma membrane (PM) induces the translocation of G protein βγ dimers to the GA. However, the functional significance of this translocation is largely unknown. Here, we study PM-GA translocation of all 12 Gγ subunits in response to chemokine receptor CXCR4 activation and demonstrate that Gγ9 is a unique Golgi-translocating Gγ subunit. CRISPR-Cas9-mediated knockout of Gγ9 abolishes activation of extracellular signal-regulated kinase 1 and 2 (ERK1/2), two members of the mitogen-activated protein kinase family, by CXCR4. We show that chemically induced recruitment to the GA of Gβγ dimers containing different Gγ subunits activates ERK1/2, whereas recruitment to the PM is ineffective. We also demonstrate that pharmacological inhibition of phosphoinositide 3-kinase γ (PI3Kγ) and depletion of its subunits p110γ and p101 abrogate ERK1/2 activation by CXCR4 and Gβγ recruitment to the GA. Knockout of either Gγ9 or PI3Kγ significantly suppresses prostate cancer PC3 cell migration, invasion, and metastasis. Collectively, our data demonstrate a novel function for Gβγ translocation to the GA, via activating PI3Kγ heterodimers p110γ-p101, to spatiotemporally regulate mitogen-activated protein kinase activation by G protein-coupled receptors and ultimately control tumor progression."xsd:string |
| http://purl.uniprot.org/citations/33493514 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jbc.2021.100325"xsd:string |
| http://purl.uniprot.org/citations/33493514 | http://purl.uniprot.org/core/author | "Huang W."xsd:string |
| http://purl.uniprot.org/citations/33493514 | http://purl.uniprot.org/core/author | "Wu G."xsd:string |
| http://purl.uniprot.org/citations/33493514 | http://purl.uniprot.org/core/author | "Wei Z."xsd:string |
| http://purl.uniprot.org/citations/33493514 | http://purl.uniprot.org/core/author | "Xu X."xsd:string |
| http://purl.uniprot.org/citations/33493514 | http://purl.uniprot.org/core/author | "Lambert N.A."xsd:string |
| http://purl.uniprot.org/citations/33493514 | http://purl.uniprot.org/core/author | "Lokeshwar B.L."xsd:string |
| http://purl.uniprot.org/citations/33493514 | http://purl.uniprot.org/core/author | "Khater M."xsd:string |
| http://purl.uniprot.org/citations/33493514 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33493514 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/33493514 | http://purl.uniprot.org/core/pages | "100325"xsd:string |
| http://purl.uniprot.org/citations/33493514 | http://purl.uniprot.org/core/title | "G protein betagamma translocation to the Golgi apparatus activates MAPK via p110gamma-p101 heterodimers."xsd:string |
| http://purl.uniprot.org/citations/33493514 | http://purl.uniprot.org/core/volume | "296"xsd:string |
| http://purl.uniprot.org/citations/33493514 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33493514 |
| http://purl.uniprot.org/citations/33493514 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33493514 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3W5-mappedCitation-33493514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33493514 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3W9-mappedCitation-33493514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33493514 |
| http://purl.uniprot.org/uniprot/#_A0A510GJR7-mappedCitation-33493514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33493514 |
| http://purl.uniprot.org/uniprot/#_A0A0U3FJG0-mappedCitation-33493514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33493514 |
| http://purl.uniprot.org/uniprot/#_A0A0U3GXA9-mappedCitation-33493514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33493514 |
| http://purl.uniprot.org/uniprot/#_A0A8Q3WLL1-mappedCitation-33493514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33493514 |
| http://purl.uniprot.org/uniprot/#_A8K9G9-mappedCitation-33493514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33493514 |
| http://purl.uniprot.org/uniprot/#_Q24M88-mappedCitation-33493514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33493514 |