| http://purl.uniprot.org/citations/33501917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33501917 | http://www.w3.org/2000/01/rdf-schema#comment | "The specification of cartilage requires Sox9, a transcription factor with broad roles for organogenesis outside the skeletal system. How Sox9 and other factors gain access to cartilage-specific cis-regulatory regions during skeletal development was unknown. By analyzing chromatin accessibility during the differentiation of neural crest cells into chondrocytes of the zebrafish head, we find that cartilage-associated chromatin accessibility is dynamically established. Cartilage-associated regions that become accessible after neural crest migration are co-enriched for Sox9 and Fox transcription factor binding motifs. In zebrafish lacking Foxc1 paralogs, we find a global decrease in chromatin accessibility in chondrocytes, consistent with a later loss of dorsal facial cartilages. Zebrafish transgenesis assays confirm that many of these Foxc1-dependent elements function as enhancers with region- and stage-specific activity in facial cartilages. These results show that Foxc1 promotes chondrogenesis in the face by establishing chromatin accessibility at a number of cartilage-associated gene enhancers."xsd:string |
| http://purl.uniprot.org/citations/33501917 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.63595"xsd:string |
| http://purl.uniprot.org/citations/33501917 | http://purl.uniprot.org/core/author | "Xu P."xsd:string |
| http://purl.uniprot.org/citations/33501917 | http://purl.uniprot.org/core/author | "Fabian P."xsd:string |
| http://purl.uniprot.org/citations/33501917 | http://purl.uniprot.org/core/author | "Crump J.G."xsd:string |
| http://purl.uniprot.org/citations/33501917 | http://purl.uniprot.org/core/author | "Segil N."xsd:string |
| http://purl.uniprot.org/citations/33501917 | http://purl.uniprot.org/core/author | "Yu H.V."xsd:string |
| http://purl.uniprot.org/citations/33501917 | http://purl.uniprot.org/core/author | "Tseng K.C."xsd:string |
| http://purl.uniprot.org/citations/33501917 | http://purl.uniprot.org/core/author | "Flath M."xsd:string |
| http://purl.uniprot.org/citations/33501917 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33501917 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/33501917 | http://purl.uniprot.org/core/pages | "e63595"xsd:string |
| http://purl.uniprot.org/citations/33501917 | http://purl.uniprot.org/core/title | "Foxc1 establishes enhancer accessibility for craniofacial cartilage differentiation."xsd:string |
| http://purl.uniprot.org/citations/33501917 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/33501917 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33501917 |
| http://purl.uniprot.org/citations/33501917 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33501917 |
| http://purl.uniprot.org/uniprot/#_Q9DE25-mappedCitation-33501917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33501917 |
| http://purl.uniprot.org/uniprot/Q9DE25 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33501917 |