| http://purl.uniprot.org/citations/33511454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33511454 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor-associated macrophages (TAMs) are abundant in solid tumors where they exhibit immunosuppressive and pro-tumorigenic functions. Inhibition of TAM proliferation and survival through CSF1R blockade has been widely explored as a cancer immunotherapy. To further define mechanisms regulating CSF1R-targeted therapies, we systematically evaluated the effect of anti-CSF1R treatment on tumor growth and tumor microenvironment (TME) inflammation across multiple murine models. Despite substantial macrophage depletion, anti-CSF1R had minimal effects on the anti-tumor immune response in mice bearing established tumors. In contrast, anti-CSF1R treatment concurrent with tumor implantation resulted in more robust tumor growth inhibition and evidence of enhanced anti-tumor immunity. Our findings suggest only minor contributions of CSF1R-dependent TAMs to the inflammatory state of the TME in established tumors, that immune landscape heterogeneity across different tumor models can influence anti-CSF1R activity, and that alternative treatment schedules and/or TAM depletion strategies may be needed to maximize the clinical benefit of this approach."xsd:string |
| http://purl.uniprot.org/citations/33511454 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00262-021-02861-3"xsd:string |
| http://purl.uniprot.org/citations/33511454 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/33511454 | http://purl.uniprot.org/core/author | "Tan H."xsd:string |
| http://purl.uniprot.org/citations/33511454 | http://purl.uniprot.org/core/author | "Orf J."xsd:string |
| http://purl.uniprot.org/citations/33511454 | http://purl.uniprot.org/core/author | "Egen J.G."xsd:string |
| http://purl.uniprot.org/citations/33511454 | http://purl.uniprot.org/core/author | "DeVoss J."xsd:string |
| http://purl.uniprot.org/citations/33511454 | http://purl.uniprot.org/core/author | "O'Brien S.A."xsd:string |
| http://purl.uniprot.org/citations/33511454 | http://purl.uniprot.org/core/author | "Skrzypczynska K.M."xsd:string |
| http://purl.uniprot.org/citations/33511454 | http://purl.uniprot.org/core/author | "Belmontes B."xsd:string |
| http://purl.uniprot.org/citations/33511454 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33511454 | http://purl.uniprot.org/core/name | "Cancer Immunol Immunother"xsd:string |
| http://purl.uniprot.org/citations/33511454 | http://purl.uniprot.org/core/pages | "2401-2410"xsd:string |
| http://purl.uniprot.org/citations/33511454 | http://purl.uniprot.org/core/title | "Activity of tumor-associated macrophage depletion by CSF1R blockade is highly dependent on the tumor model and timing of treatment."xsd:string |
| http://purl.uniprot.org/citations/33511454 | http://purl.uniprot.org/core/volume | "70"xsd:string |
| http://purl.uniprot.org/citations/33511454 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33511454 |
| http://purl.uniprot.org/citations/33511454 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33511454 |
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| http://purl.uniprot.org/uniprot/#_Q3U4N8-mappedCitation-33511454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33511454 |
| http://purl.uniprot.org/uniprot/#_Q3UKC6-mappedCitation-33511454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33511454 |
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| http://purl.uniprot.org/uniprot/#_Q0P635-mappedCitation-33511454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33511454 |
| http://purl.uniprot.org/uniprot/#_Q3TAZ7-mappedCitation-33511454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33511454 |
| http://purl.uniprot.org/uniprot/#_Q3TBH6-mappedCitation-33511454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33511454 |