| http://purl.uniprot.org/citations/33527895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33527895 | http://www.w3.org/2000/01/rdf-schema#comment | "Understanding how injury to the central nervous system induces de novo neurogenesis in animals would help promote regeneration in humans. Regenerative neurogenesis could originate from glia and glial neuron-glia antigen-2 (NG2) may sense injury-induced neuronal signals, but these are unknown. Here, we used Drosophila to search for genes functionally related to the NG2 homologue kon-tiki (kon), and identified Islet Antigen-2 (Ia-2), required in neurons for insulin secretion. Both loss and over-expression of ia-2 induced neural stem cell gene expression, injury increased ia-2 expression and induced ectopic neural stem cells. Using genetic analysis and lineage tracing, we demonstrate that Ia-2 and Kon regulate Drosophila insulin-like peptide 6 (Dilp-6) to induce glial proliferation and neural stem cells from glia. Ectopic neural stem cells can divide, and limited de novo neurogenesis could be traced back to glial cells. Altogether, Ia-2 and Dilp-6 drive a neuron-glia relay that restores glia and reprogrammes glia into neural stem cells for regeneration."xsd:string |
| http://purl.uniprot.org/citations/33527895 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.58756"xsd:string |
| http://purl.uniprot.org/citations/33527895 | http://purl.uniprot.org/core/author | "Sun J."xsd:string |
| http://purl.uniprot.org/citations/33527895 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/33527895 | http://purl.uniprot.org/core/author | "Hidalgo A."xsd:string |
| http://purl.uniprot.org/citations/33527895 | http://purl.uniprot.org/core/author | "Connolly E."xsd:string |
| http://purl.uniprot.org/citations/33527895 | http://purl.uniprot.org/core/author | "Moreira M."xsd:string |
| http://purl.uniprot.org/citations/33527895 | http://purl.uniprot.org/core/author | "Altenhein B."xsd:string |
| http://purl.uniprot.org/citations/33527895 | http://purl.uniprot.org/core/author | "Harrison N.J."xsd:string |
| http://purl.uniprot.org/citations/33527895 | http://purl.uniprot.org/core/author | "Gascon Gubieda A."xsd:string |
| http://purl.uniprot.org/citations/33527895 | http://purl.uniprot.org/core/author | "Losada Perez M."xsd:string |
| http://purl.uniprot.org/citations/33527895 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33527895 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/33527895 | http://purl.uniprot.org/core/pages | "e58756"xsd:string |
| http://purl.uniprot.org/citations/33527895 | http://purl.uniprot.org/core/title | "Regenerative neurogenic response from glia requires insulin-driven neuron-glia communication."xsd:string |
| http://purl.uniprot.org/citations/33527895 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/33527895 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33527895 |
| http://purl.uniprot.org/citations/33527895 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33527895 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFW0-mappedCitation-33527895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33527895 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEN4-mappedCitation-33527895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33527895 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KER2-mappedCitation-33527895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33527895 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LF49-mappedCitation-33527895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33527895 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6Q6-mappedCitation-33527895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33527895 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6X2-mappedCitation-33527895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33527895 |