| http://purl.uniprot.org/citations/33529594 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33529594 | http://www.w3.org/2000/01/rdf-schema#comment | "The Parkin co-regulated gene protein (PACRG) binds at the inner junction between doublet microtubules of the axoneme, a structure found in flagella and cilia. PACRG binds to the adaptor protein meiosis expressed gene 1 (MEIG1), but how they bind to microtubules is unknown. Here, we report the crystal structure of human PACRG in complex with MEIG1. PACRG adopts a helical repeat fold with a loop that interacts with MEIG1. Using the structure of the axonemal doublet microtubule from the protozoan Chlamydomonas reinhardtii and single-molecule fluorescence microscopy, we propose that PACRG binds to microtubules while simultaneously recruiting free tubulin to catalyze formation of the inner junction. We show that the homologous PACRG-like protein also mediates dual tubulin interactions but does not bind MEIG1. Our findings establish a framework to assess the function of the PACRG family of proteins and MEIG1 in regulating axoneme assembly."xsd:string |
| http://purl.uniprot.org/citations/33529594 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2021.01.001"xsd:string |
| http://purl.uniprot.org/citations/33529594 | http://purl.uniprot.org/core/author | "Ichikawa M."xsd:string |
| http://purl.uniprot.org/citations/33529594 | http://purl.uniprot.org/core/author | "Kurinov I."xsd:string |
| http://purl.uniprot.org/citations/33529594 | http://purl.uniprot.org/core/author | "Khan N."xsd:string |
| http://purl.uniprot.org/citations/33529594 | http://purl.uniprot.org/core/author | "Trempe J.F."xsd:string |
| http://purl.uniprot.org/citations/33529594 | http://purl.uniprot.org/core/author | "Chaaban S."xsd:string |
| http://purl.uniprot.org/citations/33529594 | http://purl.uniprot.org/core/author | "Bui K.H."xsd:string |
| http://purl.uniprot.org/citations/33529594 | http://purl.uniprot.org/core/author | "Black C."xsd:string |
| http://purl.uniprot.org/citations/33529594 | http://purl.uniprot.org/core/author | "Bechstedt S."xsd:string |
| http://purl.uniprot.org/citations/33529594 | http://purl.uniprot.org/core/author | "McAlear T.S."xsd:string |
| http://purl.uniprot.org/citations/33529594 | http://purl.uniprot.org/core/author | "Brouhard G."xsd:string |
| http://purl.uniprot.org/citations/33529594 | http://purl.uniprot.org/core/author | "Croteau N."xsd:string |
| http://purl.uniprot.org/citations/33529594 | http://purl.uniprot.org/core/author | "Pelletier D."xsd:string |
| http://purl.uniprot.org/citations/33529594 | http://purl.uniprot.org/core/author | "Bayne A.N."xsd:string |
| http://purl.uniprot.org/citations/33529594 | http://purl.uniprot.org/core/author | "Khalifa A.A.Z."xsd:string |
| http://purl.uniprot.org/citations/33529594 | http://purl.uniprot.org/core/author | "Veyron S."xsd:string |
| http://purl.uniprot.org/citations/33529594 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33529594 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/33529594 | http://purl.uniprot.org/core/pages | "572-586.e6"xsd:string |
| http://purl.uniprot.org/citations/33529594 | http://purl.uniprot.org/core/title | "Crystal structure of human PACRG in complex with MEIG1 reveals roles in axoneme formation and tubulin binding."xsd:string |
| http://purl.uniprot.org/citations/33529594 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/33529594 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33529594 |
| http://purl.uniprot.org/citations/33529594 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33529594 |