| http://purl.uniprot.org/citations/33534942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33534942 | http://www.w3.org/2000/01/rdf-schema#comment | "Type 1 diabetes in non-obese diabetic (NOD) mice occurs when autoreactive T cells eliminate insulin producing pancreatic β cells. While extensively studied in T-cell receptor (TCR) transgenic mice, the contribution of alterations in thymic selection to the polyclonal T-cell pool in NOD mice is not yet resolved. The magnitude of signals downstream of TCR engagement with self-peptide directs the development of a functional T-cell pool, in part by ensuring tolerance to self. TCR interactions with self-peptide are also necessary for T-cell homeostasis in the peripheral lymphoid organs. To identify differences in TCR signal strength that accompany thymic selection and peripheral T-cell maintenance, we compared CD5 levels, a marker of basal TCR signal strength, on immature and mature T cells from autoimmune diabetes-prone NOD and -resistant B6 mice. The data suggest that there is no preferential selection of NOD thymocytes that perceive stronger TCR signals from self-peptide engagement. Instead, NOD mice have an MHC-dependent increase in CD4+ thymocytes and mature T cells that express lower levels of CD5. In contrast, T cell-intrinsic mechanisms lead to higher levels of CD5 on peripheral CD8+ T cells from NOD relative to B6 mice, suggesting that peripheral CD8+ T cells with higher basal TCR signals may have survival advantages in NOD mice. These differences in the T-cell pool in NOD mice may contribute to the development or progression of autoimmune diabetes."xsd:string |
| http://purl.uniprot.org/citations/33534942 | http://purl.org/dc/terms/identifier | "doi:10.1111/imcb.12443"xsd:string |
| http://purl.uniprot.org/citations/33534942 | http://purl.uniprot.org/core/author | "Dong M."xsd:string |
| http://purl.uniprot.org/citations/33534942 | http://purl.uniprot.org/core/author | "Lesage S."xsd:string |
| http://purl.uniprot.org/citations/33534942 | http://purl.uniprot.org/core/author | "Melichar H.J."xsd:string |
| http://purl.uniprot.org/citations/33534942 | http://purl.uniprot.org/core/author | "Adegoke A."xsd:string |
| http://purl.uniprot.org/citations/33534942 | http://purl.uniprot.org/core/author | "Anderson C.C."xsd:string |
| http://purl.uniprot.org/citations/33534942 | http://purl.uniprot.org/core/author | "Lebel M.E."xsd:string |
| http://purl.uniprot.org/citations/33534942 | http://purl.uniprot.org/core/author | "Audiger C."xsd:string |
| http://purl.uniprot.org/citations/33534942 | http://purl.uniprot.org/core/author | "Valbon S.F."xsd:string |
| http://purl.uniprot.org/citations/33534942 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33534942 | http://purl.uniprot.org/core/name | "Immunol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/33534942 | http://purl.uniprot.org/core/pages | "656-667"xsd:string |
| http://purl.uniprot.org/citations/33534942 | http://purl.uniprot.org/core/title | "CD5 levels reveal distinct basal T-cell receptor signals in T cells from non-obese diabetic mice."xsd:string |
| http://purl.uniprot.org/citations/33534942 | http://purl.uniprot.org/core/volume | "99"xsd:string |
| http://purl.uniprot.org/citations/33534942 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33534942 |
| http://purl.uniprot.org/citations/33534942 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33534942 |
| http://purl.uniprot.org/uniprot/#_P13379-mappedCitation-33534942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33534942 |
| http://purl.uniprot.org/uniprot/#_Q3UP78-mappedCitation-33534942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33534942 |
| http://purl.uniprot.org/uniprot/#_Q91X69-mappedCitation-33534942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33534942 |
| http://purl.uniprot.org/uniprot/#_Q9ER20-mappedCitation-33534942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33534942 |
| http://purl.uniprot.org/uniprot/#_Q8C9H0-mappedCitation-33534942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33534942 |
| http://purl.uniprot.org/uniprot/Q91X69 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33534942 |
| http://purl.uniprot.org/uniprot/P13379 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33534942 |