| http://purl.uniprot.org/citations/33536617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33536617 | http://www.w3.org/2000/01/rdf-schema#comment | "The germinal centre is a dynamic microenvironment in which B cells that express high-affinity antibody variants produced by somatic hypermutation are selected for clonal expansion by limiting the numbers of T follicular helper cells1,2. Although much is known about the mechanisms that control the selection of B cells in the germinal centre, far less is understood about the clonal behaviour of the T follicular helper cells that help to regulate this process. Here we report on the dynamic behaviour of T follicular helper cell clones during the germinal centre reaction. We find that, similar to germinal centre B cells, T follicular helper cells undergo antigen-dependent selection throughout the germinal centre reaction that results in differential proliferative expansion and contraction. Increasing the amount of antigen presented in the germinal centre leads to increased division of T follicular helper cells. Competition between T follicular helper cell clones is mediated by the affinity of T cell receptors for peptide-major-histocompatibility-complex ligands. T cells that preferentially expand in the germinal centre show increased expression of genes downstream of the T cell receptor, such as those required for metabolic reprogramming, cell division and cytokine production. These dynamic changes lead to marked remodelling of the functional T follicular helper cell repertoire during the germinal centre reaction."xsd:string |
| http://purl.uniprot.org/citations/33536617 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41586-021-03187-x"xsd:string |
| http://purl.uniprot.org/citations/33536617 | http://purl.uniprot.org/core/author | "Chait B.T."xsd:string |
| http://purl.uniprot.org/citations/33536617 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/33536617 | http://purl.uniprot.org/core/author | "Nussenzweig M.C."xsd:string |
| http://purl.uniprot.org/citations/33536617 | http://purl.uniprot.org/core/author | "Kraft J."xsd:string |
| http://purl.uniprot.org/citations/33536617 | http://purl.uniprot.org/core/author | "Gazumyan A."xsd:string |
| http://purl.uniprot.org/citations/33536617 | http://purl.uniprot.org/core/author | "Oliveira T.Y."xsd:string |
| http://purl.uniprot.org/citations/33536617 | http://purl.uniprot.org/core/author | "Hartweger H."xsd:string |
| http://purl.uniprot.org/citations/33536617 | http://purl.uniprot.org/core/author | "Ramos V."xsd:string |
| http://purl.uniprot.org/citations/33536617 | http://purl.uniprot.org/core/author | "Olinares P.D.B."xsd:string |
| http://purl.uniprot.org/citations/33536617 | http://purl.uniprot.org/core/author | "Cipolla M."xsd:string |
| http://purl.uniprot.org/citations/33536617 | http://purl.uniprot.org/core/author | "Merkenschlager J."xsd:string |
| http://purl.uniprot.org/citations/33536617 | http://purl.uniprot.org/core/author | "Finkin S."xsd:string |
| http://purl.uniprot.org/citations/33536617 | http://purl.uniprot.org/core/author | "Nowosad C.R."xsd:string |
| http://purl.uniprot.org/citations/33536617 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33536617 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/33536617 | http://purl.uniprot.org/core/pages | "458-463"xsd:string |
| http://purl.uniprot.org/citations/33536617 | http://purl.uniprot.org/core/title | "Dynamic regulation of TFH selection during the germinal centre reaction."xsd:string |
| http://purl.uniprot.org/citations/33536617 | http://purl.uniprot.org/core/volume | "591"xsd:string |
| http://purl.uniprot.org/citations/33536617 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33536617 |
| http://purl.uniprot.org/citations/33536617 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33536617 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YW25-mappedCitation-33536617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33536617 |
| http://purl.uniprot.org/uniprot/#_A2AW86-mappedCitation-33536617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33536617 |