| http://purl.uniprot.org/citations/33548203 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33548203 | http://www.w3.org/2000/01/rdf-schema#comment | "The Integrator is a specialized 3' end-processing complex involved in cleavage and transcription termination of a subset of nascent RNA polymerase II transcripts, including small nuclear RNAs (snRNAs). We provide evidence of the modular nature of the Integrator complex by biochemically characterizing its two subcomplexes, INTS5/8 and INTS10/13/14. Using cryoelectron microscopy (cryo-EM), we determined a 3.5-Å-resolution structure of the INTS4/9/11 ternary complex, which constitutes Integrator's catalytic core. Our structure reveals the spatial organization of the catalytic nuclease INTS11, bound to its catalytically impaired homolog INTS9 via several interdependent interfaces. INTS4, a helical repeat protein, plays a key role in stabilizing nuclease domains and other components. In this assembly, all three proteins form a composite electropositive groove, suggesting a putative RNA binding path within the complex. Comparison with other 3' end-processing machineries points to distinct features and a unique architecture of the Integrator's catalytic module."xsd:string |
| http://purl.uniprot.org/citations/33548203 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2021.01.005"xsd:string |
| http://purl.uniprot.org/citations/33548203 | http://purl.uniprot.org/core/author | "Galej W.P."xsd:string |
| http://purl.uniprot.org/citations/33548203 | http://purl.uniprot.org/core/author | "Pfleiderer M.M."xsd:string |
| http://purl.uniprot.org/citations/33548203 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33548203 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/33548203 | http://purl.uniprot.org/core/pages | "1246-1259.e8"xsd:string |
| http://purl.uniprot.org/citations/33548203 | http://purl.uniprot.org/core/title | "Structure of the catalytic core of the Integrator complex."xsd:string |
| http://purl.uniprot.org/citations/33548203 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/33548203 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33548203 |
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