| http://purl.uniprot.org/citations/33563972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33563972 | http://www.w3.org/2000/01/rdf-schema#comment | "Given their copy number differences and unique modes of inheritance, the evolved gene content and expression of sex chromosomes is unusual. In many organisms the X and Y chromosomes are inactivated in spermatocytes, possibly as a defense mechanism against insertions into unpaired chromatin. In addition to current sex chromosomes, Drosophila has a small gene-poor X-chromosome relic (4th) that re-acquired autosomal status. Here we use single cell RNA-Seq on fly larvae to demonstrate that the single X and pair of 4th chromosomes are specifically inactivated in primary spermatocytes, based on measuring all genes or a set of broadly expressed genes in testis we identified. In contrast, genes on the single Y chromosome become maximally active in primary spermatocytes. Reduced X transcript levels are due to failed activation of RNA-Polymerase-II by phosphorylation of Serine 2 and 5."xsd:string |
| http://purl.uniprot.org/citations/33563972 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-021-20897-y"xsd:string |
| http://purl.uniprot.org/citations/33563972 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/33563972 | http://purl.uniprot.org/core/author | "Smith H.E."xsd:string |
| http://purl.uniprot.org/citations/33563972 | http://purl.uniprot.org/core/author | "Yu K."xsd:string |
| http://purl.uniprot.org/citations/33563972 | http://purl.uniprot.org/core/author | "Sartorelli V."xsd:string |
| http://purl.uniprot.org/citations/33563972 | http://purl.uniprot.org/core/author | "Rusan N.M."xsd:string |
| http://purl.uniprot.org/citations/33563972 | http://purl.uniprot.org/core/author | "Ross E."xsd:string |
| http://purl.uniprot.org/citations/33563972 | http://purl.uniprot.org/core/author | "Oliver B."xsd:string |
| http://purl.uniprot.org/citations/33563972 | http://purl.uniprot.org/core/author | "Conlon K."xsd:string |
| http://purl.uniprot.org/citations/33563972 | http://purl.uniprot.org/core/author | "Galletta B.J."xsd:string |
| http://purl.uniprot.org/citations/33563972 | http://purl.uniprot.org/core/author | "Dell'Orso S."xsd:string |
| http://purl.uniprot.org/citations/33563972 | http://purl.uniprot.org/core/author | "Cabral-de-Mello D.C."xsd:string |
| http://purl.uniprot.org/citations/33563972 | http://purl.uniprot.org/core/author | "Palacios-Gimenez O.M."xsd:string |
| http://purl.uniprot.org/citations/33563972 | http://purl.uniprot.org/core/author | "Vibranovski M.D."xsd:string |
| http://purl.uniprot.org/citations/33563972 | http://purl.uniprot.org/core/author | "Matunis E."xsd:string |
| http://purl.uniprot.org/citations/33563972 | http://purl.uniprot.org/core/author | "Mahadevaraju S."xsd:string |
| http://purl.uniprot.org/citations/33563972 | http://purl.uniprot.org/core/author | "Fear J.M."xsd:string |
| http://purl.uniprot.org/citations/33563972 | http://purl.uniprot.org/core/author | "Mendonca C.A."xsd:string |
| http://purl.uniprot.org/citations/33563972 | http://purl.uniprot.org/core/author | "Akeju M."xsd:string |
| http://purl.uniprot.org/citations/33563972 | http://purl.uniprot.org/core/author | "Avelino C.C."xsd:string |
| http://purl.uniprot.org/citations/33563972 | http://purl.uniprot.org/core/author | "Demere Z."xsd:string |
| http://purl.uniprot.org/citations/33563972 | http://purl.uniprot.org/core/author | "Mansuria K."xsd:string |
| http://purl.uniprot.org/citations/33563972 | http://purl.uniprot.org/core/author | "Pinheiro M.M.L.S."xsd:string |