| http://purl.uniprot.org/citations/33563975 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33563975 | http://www.w3.org/2000/01/rdf-schema#comment | "The immunosuppressive tumor microenvironment (TME) represents a major barrier for effective immunotherapy. Tumor-associated macrophages (TAMs) are highly heterogeneous and plastic cell components of the TME which can either promote tumor progression (M2-like) or boost antitumor immunity (M1-like). Here, we demonstrate that a subset of TAMs that express folate receptor β (FRβ) possess an immunosuppressive M2-like profile. In syngeneic tumor mouse models, chimeric antigen receptor (CAR)-T cell-mediated selective elimination of FRβ+ TAMs in the TME results in an enrichment of pro-inflammatory monocytes, an influx of endogenous tumor-specific CD8+ T cells, delayed tumor progression, and prolonged survival. Preconditioning of the TME with FRβ-specific CAR-T cells also improves the effectiveness of tumor-directed anti-mesothelin CAR-T cells, while simultaneous co-administration of both CAR products does not. These results highlight the pro-tumor role of FRβ+ TAMs in the TME and the therapeutic implications of TAM-depleting agents as preparative adjuncts to conventional immunotherapies that directly target tumor antigens."xsd:string |
| http://purl.uniprot.org/citations/33563975 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-021-20893-2"xsd:string |
| http://purl.uniprot.org/citations/33563975 | http://purl.uniprot.org/core/author | "Lopez G."xsd:string |
| http://purl.uniprot.org/citations/33563975 | http://purl.uniprot.org/core/author | "Matsuyama T."xsd:string |
| http://purl.uniprot.org/citations/33563975 | http://purl.uniprot.org/core/author | "Rodriguez-Garcia A."xsd:string |
| http://purl.uniprot.org/citations/33563975 | http://purl.uniprot.org/core/author | "Shaw L.C."xsd:string |
| http://purl.uniprot.org/citations/33563975 | http://purl.uniprot.org/core/author | "Lynn R.C."xsd:string |
| http://purl.uniprot.org/citations/33563975 | http://purl.uniprot.org/core/author | "Poussin M."xsd:string |
| http://purl.uniprot.org/citations/33563975 | http://purl.uniprot.org/core/author | "Powell D.J. Jr."xsd:string |
| http://purl.uniprot.org/citations/33563975 | http://purl.uniprot.org/core/author | "O'Connor R.S."xsd:string |
| http://purl.uniprot.org/citations/33563975 | http://purl.uniprot.org/core/author | "Casado-Medrano V."xsd:string |
| http://purl.uniprot.org/citations/33563975 | http://purl.uniprot.org/core/author | "Eiva M.A."xsd:string |
| http://purl.uniprot.org/citations/33563975 | http://purl.uniprot.org/core/author | "Minutolo N.G."xsd:string |
| http://purl.uniprot.org/citations/33563975 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33563975 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/33563975 | http://purl.uniprot.org/core/pages | "877"xsd:string |
| http://purl.uniprot.org/citations/33563975 | http://purl.uniprot.org/core/title | "CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy."xsd:string |
| http://purl.uniprot.org/citations/33563975 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/33563975 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33563975 |
| http://purl.uniprot.org/citations/33563975 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33563975 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQW7-mappedCitation-33563975 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33563975 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GSV4-mappedCitation-33563975 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33563975 |
| http://purl.uniprot.org/uniprot/#_P01731-mappedCitation-33563975 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33563975 |
| http://purl.uniprot.org/uniprot/#_Q3UUV7-mappedCitation-33563975 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33563975 |