| http://purl.uniprot.org/citations/33564000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33564000 | http://www.w3.org/2000/01/rdf-schema#comment | "Special AT-rich binding protein-1 (SATB1) integrates higher-order chromatin architecture with gene regulation, thereby regulating multiple signaling pathways. In mammalian cells SATB1 directly interacts with β-catenin and regulates the expression of Wnt targets by binding to their promoters. Whether SATB1 regulates Wnt/wg signaling by recruitment of β-catenin and/or its interactions with other components remains elusive. Since Wnt/Wg signaling is conserved from invertebrates to humans, we investigated SATB1 functions in regulation of Wnt/Wg signaling by using mammalian cell-lines and Drosophila. Here, we present evidence that in mammalian cells, SATB1 interacts with Dishevelled, an upstream component of the Wnt/Wg pathway. Conversely, ectopic expression of full-length human SATB1 but not that of its N- or C-terminal domains in the eye imaginal discs and salivary glands of third instar Drosophila larvae increased the expression of Wnt/Wg pathway antagonists and suppressed phenotypes associated with activated Wnt/Wg pathway. These data argue that ectopically-provided SATB1 presumably modulates Wnt/Wg signaling by acting as negative regulator in Drosophila. Interestingly, comparison of SATB1 with PDZ- and homeo-domain containing Drosophila protein Defective Proventriculus suggests that both proteins exhibit limited functional similarity in the regulation of Wnt/Wg signaling in Drosophila. Collectively, these findings indicate that regulation of Wnt/Wg pathway by SATB1 is context-dependent."xsd:string |
| http://purl.uniprot.org/citations/33564000 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-021-81324-2"xsd:string |
| http://purl.uniprot.org/citations/33564000 | http://purl.uniprot.org/core/author | "Verma S."xsd:string |
| http://purl.uniprot.org/citations/33564000 | http://purl.uniprot.org/core/author | "Mehrotra S."xsd:string |
| http://purl.uniprot.org/citations/33564000 | http://purl.uniprot.org/core/author | "Mishra R.K."xsd:string |
| http://purl.uniprot.org/citations/33564000 | http://purl.uniprot.org/core/author | "Galande S."xsd:string |
| http://purl.uniprot.org/citations/33564000 | http://purl.uniprot.org/core/author | "Deshpande G."xsd:string |
| http://purl.uniprot.org/citations/33564000 | http://purl.uniprot.org/core/author | "Kumar R.P."xsd:string |
| http://purl.uniprot.org/citations/33564000 | http://purl.uniprot.org/core/author | "Ramanujam P.L."xsd:string |
| http://purl.uniprot.org/citations/33564000 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33564000 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/33564000 | http://purl.uniprot.org/core/pages | "3385"xsd:string |
| http://purl.uniprot.org/citations/33564000 | http://purl.uniprot.org/core/title | "Global chromatin organizer SATB1 acts as a context-dependent regulator of the Wnt/Wg target genes."xsd:string |
| http://purl.uniprot.org/citations/33564000 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/33564000 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33564000 |
| http://purl.uniprot.org/citations/33564000 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33564000 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHW0-mappedCitation-33564000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33564000 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGW2-mappedCitation-33564000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33564000 |
| http://purl.uniprot.org/uniprot/#_A0A0B6XK52-mappedCitation-33564000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33564000 |
| http://purl.uniprot.org/uniprot/#_A0A126GV30-mappedCitation-33564000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33564000 |
| http://purl.uniprot.org/uniprot/#_A4V3M5-mappedCitation-33564000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33564000 |
| http://purl.uniprot.org/uniprot/#_E1JIP0-mappedCitation-33564000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33564000 |
| http://purl.uniprot.org/uniprot/#_A0A1Z1CN92-mappedCitation-33564000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33564000 |
| http://purl.uniprot.org/uniprot/#_A0A4D6K823-mappedCitation-33564000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33564000 |