| http://purl.uniprot.org/citations/33568475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33568475 | http://www.w3.org/2000/01/rdf-schema#comment | "Stem cell (SC) proliferation and differentiation organize tissue homeostasis. However, how SCs regulate coordinate tissue scaling in dynamic organs remain unknown. Here, we delineate SC regulations in dynamic skin. We found that interfollicular epidermal SCs (IFESCs) shape basal epidermal proliferating clusters (EPCs) in expanding abdominal epidermis of pregnant mice and proliferating plantar epidermis. EPCs consist of IFESC-derived Tbx3+-basal cells (Tbx3+-BCs) and their neighboring cells where Adam8-extracellular signal-regulated kinase signaling is activated. Clonal lineage tracing revealed that Tbx3+-BC clones emerge in the abdominal epidermis during pregnancy, followed by differentiation after parturition. In the plantar epidermis, Tbx3+-BCs are sustained as long-lived SCs to maintain EPCs invariably. We showed that Tbx3+-BCs are vasculature-dependent IFESCs and identified mechanical stretch as an external cue for the vasculature-driven EPC formation. Our results uncover vasculature-mediated IFESC regulations, which explain how the epidermis adjusts its size in orchestration with dermal constituents in dynamic skin."xsd:string |
| http://purl.uniprot.org/citations/33568475 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciadv.abd2575"xsd:string |
| http://purl.uniprot.org/citations/33568475 | http://purl.uniprot.org/core/author | "Abe K."xsd:string |
| http://purl.uniprot.org/citations/33568475 | http://purl.uniprot.org/core/author | "Fujiwara H."xsd:string |
| http://purl.uniprot.org/citations/33568475 | http://purl.uniprot.org/core/author | "Kubota Y."xsd:string |
| http://purl.uniprot.org/citations/33568475 | http://purl.uniprot.org/core/author | "Yamamoto T."xsd:string |
| http://purl.uniprot.org/citations/33568475 | http://purl.uniprot.org/core/author | "Kubo H."xsd:string |
| http://purl.uniprot.org/citations/33568475 | http://purl.uniprot.org/core/author | "Tsutsui K."xsd:string |
| http://purl.uniprot.org/citations/33568475 | http://purl.uniprot.org/core/author | "Ishibashi R."xsd:string |
| http://purl.uniprot.org/citations/33568475 | http://purl.uniprot.org/core/author | "Kidoya H."xsd:string |
| http://purl.uniprot.org/citations/33568475 | http://purl.uniprot.org/core/author | "Toyoshima F."xsd:string |
| http://purl.uniprot.org/citations/33568475 | http://purl.uniprot.org/core/author | "Kitano S."xsd:string |
| http://purl.uniprot.org/citations/33568475 | http://purl.uniprot.org/core/author | "Iizuka Y."xsd:string |
| http://purl.uniprot.org/citations/33568475 | http://purl.uniprot.org/core/author | "Miyachi H."xsd:string |
| http://purl.uniprot.org/citations/33568475 | http://purl.uniprot.org/core/author | "Sada A."xsd:string |
| http://purl.uniprot.org/citations/33568475 | http://purl.uniprot.org/core/author | "Muramatsu F."xsd:string |
| http://purl.uniprot.org/citations/33568475 | http://purl.uniprot.org/core/author | "Ichijo R."xsd:string |
| http://purl.uniprot.org/citations/33568475 | http://purl.uniprot.org/core/author | "Kabata M."xsd:string |
| http://purl.uniprot.org/citations/33568475 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33568475 | http://purl.uniprot.org/core/name | "Sci Adv"xsd:string |
| http://purl.uniprot.org/citations/33568475 | http://purl.uniprot.org/core/pages | "eabd2575"xsd:string |
| http://purl.uniprot.org/citations/33568475 | http://purl.uniprot.org/core/title | "Vasculature-driven stem cell population coordinates tissue scaling in dynamic organs."xsd:string |
| http://purl.uniprot.org/citations/33568475 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/33568475 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33568475 |