| http://purl.uniprot.org/citations/33571432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33571432 | http://www.w3.org/2000/01/rdf-schema#comment | "Dopamine receptors, including D1- and D2-like receptors, are important therapeutic targets in a variety of neurological syndromes, as well as cardiovascular and kidney diseases. Here, we present five cryoelectron microscopy (cryo-EM) structures of the dopamine D1 receptor (DRD1) coupled to Gs heterotrimer in complex with three catechol-based agonists, a non-catechol agonist, and a positive allosteric modulator for endogenous dopamine. These structures revealed that a polar interaction network is essential for catecholamine-like agonist recognition, whereas specific motifs in the extended binding pocket were responsible for discriminating D1-from D2-like receptors. Moreover, allosteric binding at a distinct inner surface pocket improved the activity of DRD1 by stabilizing endogenous dopamine interaction at the orthosteric site. DRD1-Gs interface revealed key features that serve as determinants for G protein coupling. Together, our study provides a structural understanding of the ligand recognition, allosteric regulation, and G protein coupling mechanisms of DRD1."xsd:string |
| http://purl.uniprot.org/citations/33571432 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2021.01.028"xsd:string |
| http://purl.uniprot.org/citations/33571432 | http://purl.uniprot.org/core/author | "Cao S."xsd:string |
| http://purl.uniprot.org/citations/33571432 | http://purl.uniprot.org/core/author | "Du Y."xsd:string |
| http://purl.uniprot.org/citations/33571432 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/33571432 | http://purl.uniprot.org/core/author | "Hu Z."xsd:string |
| http://purl.uniprot.org/citations/33571432 | http://purl.uniprot.org/core/author | "Kong L."xsd:string |
| http://purl.uniprot.org/citations/33571432 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/33571432 | http://purl.uniprot.org/core/author | "Shao Z."xsd:string |
| http://purl.uniprot.org/citations/33571432 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/33571432 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/33571432 | http://purl.uniprot.org/core/author | "Yan W."xsd:string |
| http://purl.uniprot.org/citations/33571432 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/33571432 | http://purl.uniprot.org/core/author | "Zhu L."xsd:string |
| http://purl.uniprot.org/citations/33571432 | http://purl.uniprot.org/core/author | "Yang S."xsd:string |
| http://purl.uniprot.org/citations/33571432 | http://purl.uniprot.org/core/author | "Wen X."xsd:string |
| http://purl.uniprot.org/citations/33571432 | http://purl.uniprot.org/core/author | "Yu X."xsd:string |
| http://purl.uniprot.org/citations/33571432 | http://purl.uniprot.org/core/author | "Yuan Y."xsd:string |
| http://purl.uniprot.org/citations/33571432 | http://purl.uniprot.org/core/author | "Yang C.C."xsd:string |
| http://purl.uniprot.org/citations/33571432 | http://purl.uniprot.org/core/author | "Wu C."xsd:string |
| http://purl.uniprot.org/citations/33571432 | http://purl.uniprot.org/core/author | "Qu C."xsd:string |
| http://purl.uniprot.org/citations/33571432 | http://purl.uniprot.org/core/author | "Rosenbaum D.M."xsd:string |
| http://purl.uniprot.org/citations/33571432 | http://purl.uniprot.org/core/author | "Xia A."xsd:string |
| http://purl.uniprot.org/citations/33571432 | http://purl.uniprot.org/core/author | "Sun J.P."xsd:string |