| http://purl.uniprot.org/citations/33571905 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33571905 | http://www.w3.org/2000/01/rdf-schema#comment | "Adenylate kinase2 (AK2) catalyzes trans-compartmental nucleotide exchange, but the functional implications of this mitochondrial intermembrane isoform is only partially understood. Here, transgenic AK2-/-null homozygosity was lethal early in embryo, indicating a mandatory role for intact AK2 in utero development. In the adult, conditional organ-specific ablation of AK2 precipitated abrupt heart failure with Krebs cycle and glycolytic metabolite buildup, suggesting a vital contribution to energy demanding cardiac performance. Depressed pump function recovered to pre-deletion levels overtime, suggestive of an adaptive response. Compensatory upregulation of phosphotransferase AK1, AK3, AK4 isozymes, creatine kinase isoforms, and hexokinase, along with remodeling of cell cycle/growth genes and mitochondrial ultrastructure supported organ rescue. Taken together, the requirement of AK2 in early embryonic stages, and the immediate collapse of heart performance in the AK2-deficient postnatal state underscore a primordial function of the AK2 isoform. Unsalvageable in embryo, loss of AK2 in the adult heart was recoverable, underscoring an AK2-integrated bioenergetics system with innate plasticity to maintain homeostasis on demand."xsd:string |
| http://purl.uniprot.org/citations/33571905 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2021.01.097"xsd:string |
| http://purl.uniprot.org/citations/33571905 | http://purl.uniprot.org/core/author | "Park S."xsd:string |
| http://purl.uniprot.org/citations/33571905 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/33571905 | http://purl.uniprot.org/core/author | "Yamada S."xsd:string |
| http://purl.uniprot.org/citations/33571905 | http://purl.uniprot.org/core/author | "Terzic A."xsd:string |
| http://purl.uniprot.org/citations/33571905 | http://purl.uniprot.org/core/author | "Kaambre T."xsd:string |
| http://purl.uniprot.org/citations/33571905 | http://purl.uniprot.org/core/author | "Dzeja P."xsd:string |
| http://purl.uniprot.org/citations/33571905 | http://purl.uniprot.org/core/author | "Klepinin A."xsd:string |
| http://purl.uniprot.org/citations/33571905 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33571905 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/33571905 | http://purl.uniprot.org/core/pages | "59-64"xsd:string |
| http://purl.uniprot.org/citations/33571905 | http://purl.uniprot.org/core/title | "Adenylate kinase AK2 isoform integral in embryo and adult heart homeostasis."xsd:string |
| http://purl.uniprot.org/citations/33571905 | http://purl.uniprot.org/core/volume | "546"xsd:string |
| http://purl.uniprot.org/citations/33571905 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33571905 |
| http://purl.uniprot.org/citations/33571905 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33571905 |
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| http://purl.uniprot.org/uniprot/#_F7BP55-mappedCitation-33571905 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33571905 |
| http://purl.uniprot.org/uniprot/#_Q5YD48-mappedCitation-33571905 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33571905 |
| http://purl.uniprot.org/uniprot/#_Q9WTP6-mappedCitation-33571905 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33571905 |
| http://purl.uniprot.org/uniprot/Q5YD48 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33571905 |
| http://purl.uniprot.org/uniprot/Q9WTP6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33571905 |
| http://purl.uniprot.org/uniprot/F7BP55 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33571905 |
| http://purl.uniprot.org/uniprot/A0A286YDF7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33571905 |