| http://purl.uniprot.org/citations/33579703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33579703 | http://www.w3.org/2000/01/rdf-schema#comment | "Uterine sensitization-associated gene-1 (USAG-1) deficiency leads to enhanced bone morphogenetic protein (BMP) signaling, leading to supernumerary teeth formation. Furthermore, antibodies interfering with binding of USAG-1 to BMP, but not lipoprotein receptor-related protein 5/6 (LRP5/6), accelerate tooth development. Since USAG-1 inhibits Wnt and BMP signals, the essential factors for tooth development, via direct binding to BMP and Wnt coreceptor LRP5/6, we hypothesized that USAG-1 plays key regulatory roles in suppressing tooth development. However, the involvement of USAG-1 in various types of congenital tooth agenesis remains unknown. Here, we show that blocking USAG-1 function through USAG-1 knockout or anti-USAG-1 antibody administration relieves congenital tooth agenesis caused by various genetic abnormalities in mice. Our results demonstrate that USAG-1 controls the number of teeth by inhibiting development of potential tooth germs in wild-type or mutant mice missing teeth. Anti-USAG-1 antibody administration is, therefore, a promising approach for tooth regeneration therapy."xsd:string |
| http://purl.uniprot.org/citations/33579703 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciadv.abf1798"xsd:string |
| http://purl.uniprot.org/citations/33579703 | http://purl.uniprot.org/core/author | "Takahashi K."xsd:string |
| http://purl.uniprot.org/citations/33579703 | http://purl.uniprot.org/core/author | "Sugai M."xsd:string |
| http://purl.uniprot.org/citations/33579703 | http://purl.uniprot.org/core/author | "Takagi J."xsd:string |
| http://purl.uniprot.org/citations/33579703 | http://purl.uniprot.org/core/author | "Tabata Y."xsd:string |
| http://purl.uniprot.org/citations/33579703 | http://purl.uniprot.org/core/author | "Mihara E."xsd:string |
| http://purl.uniprot.org/citations/33579703 | http://purl.uniprot.org/core/author | "Tokita Y."xsd:string |
| http://purl.uniprot.org/citations/33579703 | http://purl.uniprot.org/core/author | "Nambu Y."xsd:string |
| http://purl.uniprot.org/citations/33579703 | http://purl.uniprot.org/core/author | "Bessho K."xsd:string |
| http://purl.uniprot.org/citations/33579703 | http://purl.uniprot.org/core/author | "Murashima-Suginami A."xsd:string |
| http://purl.uniprot.org/citations/33579703 | http://purl.uniprot.org/core/author | "Kiso H."xsd:string |
| http://purl.uniprot.org/citations/33579703 | http://purl.uniprot.org/core/author | "Uozumi R."xsd:string |
| http://purl.uniprot.org/citations/33579703 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33579703 | http://purl.uniprot.org/core/name | "Sci Adv"xsd:string |
| http://purl.uniprot.org/citations/33579703 | http://purl.uniprot.org/core/pages | "eabf1798"xsd:string |
| http://purl.uniprot.org/citations/33579703 | http://purl.uniprot.org/core/title | "Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling."xsd:string |
| http://purl.uniprot.org/citations/33579703 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/33579703 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33579703 |
| http://purl.uniprot.org/citations/33579703 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33579703 |
| http://purl.uniprot.org/uniprot/#_Q1L2D6-mappedCitation-33579703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33579703 |
| http://purl.uniprot.org/uniprot/#_Q1L2D8-mappedCitation-33579703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33579703 |
| http://purl.uniprot.org/uniprot/#_Q1L2D9-mappedCitation-33579703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33579703 |
| http://purl.uniprot.org/uniprot/#_Q1L2E0-mappedCitation-33579703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33579703 |