| http://purl.uniprot.org/citations/33579907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33579907 | http://www.w3.org/2000/01/rdf-schema#comment | "Erythropoietin (EPO) is not only an erythropoiesis hormone but also an immune-regulatory cytokine. The receptors of EPO (EPOR)2 and tissue-protective receptor (TPR), mediate EPO's immune regulation. Our group firstly reported a non-erythropoietic peptide derivant of EPO, cyclic helix B peptide (CHBP), which could inhibit macrophages inflammation and dendritic cells (DCs) maturation. As a kind of innate immune regulatory cell, myeloid-derived suppressor cells (MDSCs) share a common myeloid progenitor with macrophages and DCs. In this study, we investigated the effects on MDSCs differentiation and immunosuppressive function via CHBP induction. CHBP promoted MDSCs differentiate toward M-MDSCs with enhanced immunosuppressive capability. Infusion of CHBP-induced M-MDSCs significantly prolonged murine skin allograft survival compared to its counterpart without CHBP stimulation. In addition, we found CHBP increased the proportion of CD11b+Ly6G-Ly6Chigh CD127+ M-MDSCs, which exerted a stronger immunosuppressive function compared to CD11b+Ly6G-Ly6Chigh CD127- M-MDSCs. In CHBP induced M-MDSCs, we found that EPOR downstream signal proteins Jak2 and STAT3 were upregulated, which had a strong relationship with MDSC function. In addition, CHBP upregulated GATA-binding protein 3 (GATA-3) protein translation level, which was an upstream signal of CD127 and regulator of STAT3. These effects of CHBP could be reversed if Epor was deficient. Our novel findings identified a new subset of M-MDSCs with better immunosuppressive capability, which was induced by the EPOR-mediated Jak2/GATA3/STAT3 pathway. These results are beneficial for CHBP clinical translation and MDSC cell therapy in the future."xsd:string |
| http://purl.uniprot.org/citations/33579907 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41419-021-03448-7"xsd:string |
| http://purl.uniprot.org/citations/33579907 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/33579907 | http://purl.uniprot.org/core/author | "Qiu Y."xsd:string |
| http://purl.uniprot.org/citations/33579907 | http://purl.uniprot.org/core/author | "Sun T."xsd:string |
| http://purl.uniprot.org/citations/33579907 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/33579907 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/33579907 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/33579907 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/33579907 | http://purl.uniprot.org/core/author | "Yang C."xsd:string |
| http://purl.uniprot.org/citations/33579907 | http://purl.uniprot.org/core/author | "Zhu T."xsd:string |
| http://purl.uniprot.org/citations/33579907 | http://purl.uniprot.org/core/author | "Rong R."xsd:string |
| http://purl.uniprot.org/citations/33579907 | http://purl.uniprot.org/core/author | "Tu G."xsd:string |
| http://purl.uniprot.org/citations/33579907 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33579907 | http://purl.uniprot.org/core/name | "Cell Death Dis"xsd:string |
| http://purl.uniprot.org/citations/33579907 | http://purl.uniprot.org/core/pages | "177"xsd:string |
| http://purl.uniprot.org/citations/33579907 | http://purl.uniprot.org/core/title | "CHBP induces stronger immunosuppressive CD127+ M-MDSC via erythropoietin receptor."xsd:string |
| http://purl.uniprot.org/citations/33579907 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/33579907 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33579907 |
| http://purl.uniprot.org/citations/33579907 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33579907 |
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| http://purl.uniprot.org/uniprot/#_P14753-mappedCitation-33579907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33579907 |
| http://purl.uniprot.org/uniprot/#_Q3UTV9-mappedCitation-33579907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33579907 |
| http://purl.uniprot.org/uniprot/P14753 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33579907 |