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Background

Glutathione S-transferase omega-1 (GSTO1-1) is a cytosolic enzyme that modulates the S-thiolation status of intracellular factors involved in cancer cell survival or in the inflammatory response. Studies focusing on chronic obstructive pulmonary disease (COPD) have demonstrated that GSTO1-1 is detectable in alveolar macrophages, airway epithelium and in the extracellular compartment, where its functions have not been completely understood. Moreover GSTO1-1 polymorphisms have been associated with an increased risk to develop COPD. Against this background, the aim of this study was to evaluate GSTO1-1 levels and its polymorphisms in cystic fibrosis (CF) patients.

Methods

Clinical samples from a previous study published by our groups were analyzed for GSTO1-1 levels and polymorphisms. For comparison, a model of lung inflammation in CFTR-knock out mice was also used.

Results

Our data document that soluble GSTO1-1 can be found in the airways of CF patients and correlates with inflammatory parameters such as neutrophilic elastase and the chemokine IL-8. A negative correlation was found between GSTO1-1 levels and the spirometric parameter FEV1 and the FEV1/FVC ratio. Additionally, the A140D polymorphism of GSTO1-1 was associated with lower levels of the antiinflammatory mediators PGE2 and 15(S)-HETE, and with lower values of the FEV1/FVC ratio in CF subjects with the homozygous CFTR ΔF508 mutation.

Conclusions

Our data suggest that extracellular GSTO1-1 and its polymorphysms could have a biological and clinical significance in CF. Pathophysiological functions of GSTOs are far from being completely understood, and more studies are required to understand the role(s) of extracellular GSTO1-1 in inflamed tissues."xsd:string
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http://purl.uniprot.org/citations/33583732http://purl.uniprot.org/core/author"Griese M."xsd:string
http://purl.uniprot.org/citations/33583732http://purl.uniprot.org/core/author"Corti A."xsd:string
http://purl.uniprot.org/citations/33583732http://purl.uniprot.org/core/author"Sorio C."xsd:string
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http://purl.uniprot.org/citations/33583732http://purl.uniprot.org/core/author"Piaggi S."xsd:string
http://purl.uniprot.org/citations/33583732http://purl.uniprot.org/core/author"Carnicelli V."xsd:string
http://purl.uniprot.org/citations/33583732http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/33583732http://purl.uniprot.org/core/name"J Cyst Fibros"xsd:string
http://purl.uniprot.org/citations/33583732http://purl.uniprot.org/core/pages"1053-1061"xsd:string
http://purl.uniprot.org/citations/33583732http://purl.uniprot.org/core/title"Airways glutathione S-transferase omega-1 and its A140D polymorphism are associated with severity of inflammation and respiratory dysfunction in cystic fibrosis."xsd:string
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