| http://purl.uniprot.org/citations/33584648 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33584648 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-7 (IL-7) is an important cytokine with pivotal pro-survival functions in the adaptive immune system. However, the role of IL-7 in innate immunity is not fully understood. In the present study, the impact of hepatic IL-7 on innate immune cells was assessed by functional experiments as well as in patients with different stages of liver cirrhosis or acute-on-chronic liver failure (ACLF). Human hepatocytes and liver sinusoidal endothelial cells secreted IL-7 in response to stimulation with interferons (IFNs) of type I and II, yet not type III. De novo translation of interferon-response factor-1 (IRF-1) restricted IL-7 production to stimulation with type I and II IFNs. LPS-primed human macrophages were identified as innate immune target cells responding to IL-7 signaling by inactivation of Glycogen synthase kinase-3 (GSK3). IL-7-mediated GSK3 inactivation augmented LPS-induced secretion of pro-inflammatory cytokines and blunted LPS tolerance of macrophages. The IFN-IRF-1-IL-7 axis was present in liver cirrhosis patients. However, liver cirrhosis patients with or without ACLF had significantly lower concentrations of IL-7 in serum compared to healthy controls, which might contribute to LPS-tolerance in these patients. In conclusion, we propose the presence of an inflammatory cascade where IFNs of type I/II induce hepatocellular IL-7 in an IRF-1-restriced way. Beyond its role in adaptive immune responses, IL-7 appears to augment the response of macrophages to LPS and to ameliorate LPS tolerance, which may improve innate immune responses against invading pathogens."xsd:string |
| http://purl.uniprot.org/citations/33584648 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2020.581352"xsd:string |
| http://purl.uniprot.org/citations/33584648 | http://purl.uniprot.org/core/author | "Schmidt M."xsd:string |
| http://purl.uniprot.org/citations/33584648 | http://purl.uniprot.org/core/author | "Cai C."xsd:string |
| http://purl.uniprot.org/citations/33584648 | http://purl.uniprot.org/core/author | "Dittmer U."xsd:string |
| http://purl.uniprot.org/citations/33584648 | http://purl.uniprot.org/core/author | "Welsch C."xsd:string |
| http://purl.uniprot.org/citations/33584648 | http://purl.uniprot.org/core/author | "Zeuzem S."xsd:string |
| http://purl.uniprot.org/citations/33584648 | http://purl.uniprot.org/core/author | "Rueschenbaum S."xsd:string |
| http://purl.uniprot.org/citations/33584648 | http://purl.uniprot.org/core/author | "Lange C.M."xsd:string |
| http://purl.uniprot.org/citations/33584648 | http://purl.uniprot.org/core/author | "Schwarzkopf K."xsd:string |
| http://purl.uniprot.org/citations/33584648 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33584648 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/33584648 | http://purl.uniprot.org/core/pages | "581352"xsd:string |
| http://purl.uniprot.org/citations/33584648 | http://purl.uniprot.org/core/title | "Translation of IRF-1 Restricts Hepatic Interleukin-7 Production to Types I and II Interferons: Implications for Hepatic Immunity."xsd:string |
| http://purl.uniprot.org/citations/33584648 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/33584648 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33584648 |
| http://purl.uniprot.org/citations/33584648 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33584648 |
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