| http://purl.uniprot.org/citations/33584707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33584707 | http://www.w3.org/2000/01/rdf-schema#comment | "The antigen-independent, strong proliferative responses of naive CD8+ T cells have been well demonstrated in a particular strain of mice lacking IL-2 receptors. This type of proliferation is mainly driven by common gamma-chain (γc) cytokines, such as IL-2, IL-7, and IL-15, present at abnormally high levels in these mice. Similarly, in the present study, we showed that mice lacking Janus kinase 3 (Jak3), a tyrosine kinase crucial for γc cytokine signaling, could induce strong proliferation of adoptively transferred naive CD8+ T cells. This proliferation was also independent of antigenic stimulation, but heavily dependent on IL-2, as evidenced by the failure of proliferation of adoptively transferred IL-2 receptor alpha- and beta-chain-deficient naive CD8+ T cells. Consistent with this, Jak3-/- mice showed elevated serum levels of IL-2 compared to wild-type mice, and interestingly, IL-2 production was due to high levels of accumulation of activated CD4+ T cells in Jak3-/- mice along with defective CD4+ T regulatory cells. Collectively, these findings reveal previously unidentified unique immune contexts of Jak3-/- mice that cause robust IL-2-driven T cell expansion and have a clinical implication for designing a treatment strategy for human patients with loss-of-function genetic mutations of Jak3."xsd:string |
| http://purl.uniprot.org/citations/33584707 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2020.616898"xsd:string |
| http://purl.uniprot.org/citations/33584707 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/33584707 | http://purl.uniprot.org/core/author | "Lee S.W."xsd:string |
| http://purl.uniprot.org/citations/33584707 | http://purl.uniprot.org/core/author | "Cho J.H."xsd:string |
| http://purl.uniprot.org/citations/33584707 | http://purl.uniprot.org/core/author | "Yun C.H."xsd:string |
| http://purl.uniprot.org/citations/33584707 | http://purl.uniprot.org/core/author | "Lee G.W."xsd:string |
| http://purl.uniprot.org/citations/33584707 | http://purl.uniprot.org/core/author | "Kim H.O."xsd:string |
| http://purl.uniprot.org/citations/33584707 | http://purl.uniprot.org/core/author | "Ju Y.J."xsd:string |
| http://purl.uniprot.org/citations/33584707 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33584707 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/33584707 | http://purl.uniprot.org/core/pages | "616898"xsd:string |
| http://purl.uniprot.org/citations/33584707 | http://purl.uniprot.org/core/title | "Supraphysiological Levels of IL-2 in Jak3-Deficient Mice Promote Strong Proliferative Responses of Adoptively Transferred Naive CD8+ T Cells."xsd:string |
| http://purl.uniprot.org/citations/33584707 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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