| http://purl.uniprot.org/citations/33594251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33594251 | http://www.w3.org/2000/01/rdf-schema#comment | "The mucosa microenvironment is critical for intestinal stem cell self-renewal and reconstruction of the epithelial barrier in inflammatory bowel disease (IBD), where the mechanisms underlying cross-talk between intestinal crypts and the microenvironment remain unclear. Here, we firstly identified miR-494-3p as an important protector in colitis. miR-494-3p levels were decreased and negatively correlated with the severity in human IBD samples, as well as in colitis mice. In colitis crypts, a notable cytokine-cytokine receptor, miR-494-3p-targeted EDA2R and the ligand EDA-A2, suppressed colonic stemness and epithelial repair by inhibiting β-catenin/c-Myc. In differentiated IECs, miR-494-3p inhibits macrophage recruitment, M1 activation and EDA-A2 secretion by targeting IKKβ/NF-κB in colitis. A miR-494-3p agomir system notably ameliorated the severity of colonic colitis in vivo. Collectively, our findings uncover a miR-494-3p-mediated cross-talk mechanism by which macrophage-induced intestinal stem cell impairment aggravates intestinal inflammation."xsd:string |
| http://purl.uniprot.org/citations/33594251 | http://purl.org/dc/terms/identifier | "doi:10.1038/s42003-021-01730-0"xsd:string |
| http://purl.uniprot.org/citations/33594251 | http://purl.uniprot.org/core/author | "Gao H."xsd:string |
| http://purl.uniprot.org/citations/33594251 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/33594251 | http://purl.uniprot.org/core/author | "Lu L."xsd:string |
| http://purl.uniprot.org/citations/33594251 | http://purl.uniprot.org/core/author | "Lin R."xsd:string |
| http://purl.uniprot.org/citations/33594251 | http://purl.uniprot.org/core/author | "Lu H."xsd:string |
| http://purl.uniprot.org/citations/33594251 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/33594251 | http://purl.uniprot.org/core/author | "Song L."xsd:string |
| http://purl.uniprot.org/citations/33594251 | http://purl.uniprot.org/core/author | "Xu X."xsd:string |
| http://purl.uniprot.org/citations/33594251 | http://purl.uniprot.org/core/author | "Chang R."xsd:string |
| http://purl.uniprot.org/citations/33594251 | http://purl.uniprot.org/core/author | "Zhan L."xsd:string |
| http://purl.uniprot.org/citations/33594251 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33594251 | http://purl.uniprot.org/core/name | "Commun Biol"xsd:string |
| http://purl.uniprot.org/citations/33594251 | http://purl.uniprot.org/core/pages | "213"xsd:string |
| http://purl.uniprot.org/citations/33594251 | http://purl.uniprot.org/core/title | "Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/beta-catenin signaling in mice."xsd:string |
| http://purl.uniprot.org/citations/33594251 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/33594251 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33594251 |
| http://purl.uniprot.org/citations/33594251 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33594251 |
| http://purl.uniprot.org/uniprot/#_Q1L2D6-mappedCitation-33594251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33594251 |
| http://purl.uniprot.org/uniprot/#_Q1L2D8-mappedCitation-33594251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33594251 |
| http://purl.uniprot.org/uniprot/#_Q1L2D9-mappedCitation-33594251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33594251 |
| http://purl.uniprot.org/uniprot/#_Q1L2E0-mappedCitation-33594251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33594251 |
| http://purl.uniprot.org/uniprot/#_A0A0U5J8Q0-mappedCitation-33594251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33594251 |