DESCRIBE <http://purl.uniprot.org/citations/33595813>

Subject	Predicate	Object
http://purl.uniprot.org/citations/33595813	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/33595813	http://www.w3.org/2000/01/rdf-schema#comment	" Background In ribosome establishment and the initiation of translation, eukaryotic translation initiation factor (eIF) 3a is a pivotal functional subunit of the eIF3 complex. In various cancer types, abnormal eIF3a expression plays an important role in tumorigenesis. Objective We aimed to explore the role of eIF3a in human thyroid cancer (TC). Material and methods The expression of eIF3a was determined in TC tissues by qRT-PCR and immunohistochemistry (IHC) assay, respectively. In addition, the expression of eIF3a in K1 and BCPAP cells were detected by qRT-PCR. Cell proliferation, cell cycle, and cell apoptosis were assessed after eIF3a knockdown in K1 in cell line. Results The expression of eIF3a mRNA was high in TC tissues and cancer cell lines. Moreover, eIF3a expression in TC tissues indicated that high eIF3a level was associated with tumor grade. In addition, eIF3a knockdown resulted in a significantly decrease in cell proliferation and increased the apoptosis of K1 cells. Cell cycle was arrested in both the S and G2/M phase. The levels of phosphorylated ERK1/2 and surviving were decreased after eIF3a knockdown. Conclusion Our study suggested that eIF3a contributed to TC cell proliferation. It may be a promising target for gene therapy in human thyroid cancer."xsd:string
http://purl.uniprot.org/citations/33595813	http://purl.org/dc/terms/identifier	"doi:10.1007/s13258-021-01048-5"xsd:string
http://purl.uniprot.org/citations/33595813	http://purl.uniprot.org/core/author	"Hong S."xsd:string
http://purl.uniprot.org/citations/33595813	http://purl.uniprot.org/core/author	"Liu J."xsd:string
http://purl.uniprot.org/citations/33595813	http://purl.uniprot.org/core/author	"Jiang C."xsd:string
http://purl.uniprot.org/citations/33595813	http://purl.uniprot.org/core/author	"Wang S."xsd:string
http://purl.uniprot.org/citations/33595813	http://purl.uniprot.org/core/author	"Zheng X."xsd:string
http://purl.uniprot.org/citations/33595813	http://purl.uniprot.org/core/date	"2021"xsd:gYear
http://purl.uniprot.org/citations/33595813	http://purl.uniprot.org/core/name	"Genes Genomics"xsd:string
http://purl.uniprot.org/citations/33595813	http://purl.uniprot.org/core/pages	"379-388"xsd:string
http://purl.uniprot.org/citations/33595813	http://purl.uniprot.org/core/title	"Knockdown of eIF3a attenuated cell growth in K1 human thyroid cancer cells."xsd:string
http://purl.uniprot.org/citations/33595813	http://purl.uniprot.org/core/volume	"43"xsd:string
http://purl.uniprot.org/citations/33595813	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/33595813
http://purl.uniprot.org/citations/33595813	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/33595813
http://purl.uniprot.org/uniprot/#_Q14152-mappedCitation-33595813	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/33595813
http://purl.uniprot.org/uniprot/#_Q24JU4-mappedCitation-33595813	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/33595813
http://purl.uniprot.org/uniprot/#_Q3B770-mappedCitation-33595813	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/33595813
http://purl.uniprot.org/uniprot/#_J9R021-mappedCitation-33595813	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/33595813
http://purl.uniprot.org/uniprot/#_Q05BS0-mappedCitation-33595813	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/33595813
http://purl.uniprot.org/uniprot/#_Q6P1R0-mappedCitation-33595813	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/33595813
http://purl.uniprot.org/uniprot/#_Q7Z5T5-mappedCitation-33595813	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/33595813
http://purl.uniprot.org/uniprot/Q7Z5T5	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/33595813
http://purl.uniprot.org/uniprot/Q14152	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/33595813
http://purl.uniprot.org/uniprot/Q3B770	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/33595813