| http://purl.uniprot.org/citations/33608500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33608500 | http://www.w3.org/2000/01/rdf-schema#comment | "Dysregulation of transforming growth factor-beta (TGFβ) signaling has been implicated in liver carcinogenesis with both tumor promoting and inhibiting activities. Activation of the c-MYC protooncogene is another critical genetic event in hepatocellular carcinoma (HCC). However, the precise functional crosstalk between c-MYC and TGFβ signaling pathways remains unclear. In the present investigation, we investigated the expression of TGFβ signaling in c-MYC amplified human HCC samples as well as the mechanisms whereby TGFβ modulates c-Myc driven hepatocarcinogenesis during initiation and progression. We found that several TGFβ target genes are overexpressed in human HCCs with c-MYC amplification. In vivo, activation of TGFβ1 impaired c-Myc murine HCC initiation, whereas inhibition of TGFβ pathway accelerated this process. In contrast, overexpression of TGFβ1 enhanced c-Myc HCC progression by promoting tumor cell metastasis. Mechanistically, activation of TGFβ promoted tumor microenvironment reprogramming rather than inducing epithelial-to-mesenchymal transition during HCC progression. Moreover, we identified PMEPA1 as a potential TGFβ1 target. Altogether, our data underline the divergent roles of TGFβ signaling during c-MYC induced HCC initiation and progression."xsd:string |
| http://purl.uniprot.org/citations/33608500 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41419-021-03488-z"xsd:string |
| http://purl.uniprot.org/citations/33608500 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/33608500 | http://purl.uniprot.org/core/author | "Song X."xsd:string |
| http://purl.uniprot.org/citations/33608500 | http://purl.uniprot.org/core/author | "Xu M."xsd:string |
| http://purl.uniprot.org/citations/33608500 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/33608500 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/33608500 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/33608500 | http://purl.uniprot.org/core/author | "Zeng Y."xsd:string |
| http://purl.uniprot.org/citations/33608500 | http://purl.uniprot.org/core/author | "Evert M."xsd:string |
| http://purl.uniprot.org/citations/33608500 | http://purl.uniprot.org/core/author | "Calvisi D.F."xsd:string |
| http://purl.uniprot.org/citations/33608500 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33608500 | http://purl.uniprot.org/core/name | "Cell Death Dis"xsd:string |
| http://purl.uniprot.org/citations/33608500 | http://purl.uniprot.org/core/pages | "200"xsd:string |
| http://purl.uniprot.org/citations/33608500 | http://purl.uniprot.org/core/title | "Distinct functions of transforming growth factor-beta signaling in c-MYC driven hepatocellular carcinoma initiation and progression."xsd:string |
| http://purl.uniprot.org/citations/33608500 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/33608500 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33608500 |
| http://purl.uniprot.org/citations/33608500 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33608500 |
| http://purl.uniprot.org/uniprot/#_A0A078BBI5-mappedCitation-33608500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33608500 |
| http://purl.uniprot.org/uniprot/#_A0A078BC11-mappedCitation-33608500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33608500 |
| http://purl.uniprot.org/uniprot/#_A0A078BCJ0-mappedCitation-33608500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33608500 |
| http://purl.uniprot.org/uniprot/#_A0A078BCH8-mappedCitation-33608500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33608500 |
| http://purl.uniprot.org/uniprot/#_A0A078BFK3-mappedCitation-33608500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33608500 |
| http://purl.uniprot.org/uniprot/#_E9Q6I6-mappedCitation-33608500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33608500 |