| http://purl.uniprot.org/citations/33615517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33615517 | http://www.w3.org/2000/01/rdf-schema#comment | "5-Fluorouracil (5-FU) is a widely used chemotherapeutic drug, but the mechanisms underlying 5-FU efficacy in immunocompetent hosts in vivo remain largely elusive. Through modeling 5-FU response of murine colon and melanoma tumors, we report that effective reduction of tumor burden by 5-FU is dependent on anti-tumor immunity triggered by the activation of cancer-cell-intrinsic STING. While the loss of STING does not induce 5-FU resistance in vitro, effective 5-FU responsiveness in vivo requires cancer-cell-intrinsic cGAS, STING, and subsequent type I interferon (IFN) production, as well as IFN-sensing by bone-marrow-derived cells. In the absence of cancer-cell-intrinsic STING, a much higher dose of 5-FU is needed to reduce tumor burden. 5-FU treatment leads to increased intratumoral T cells, and T-cell depletion significantly reduces the efficacy of 5-FU in vivo. In human colorectal specimens, higher STING expression is associated with better survival and responsiveness to chemotherapy. Our results support a model in which 5-FU triggers cancer-cell-initiated anti-tumor immunity to reduce tumor burden, and our findings could be harnessed to improve therapeutic effectiveness and toxicity for colon and other cancers."xsd:string |
| http://purl.uniprot.org/citations/33615517 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.2020106065"xsd:string |
| http://purl.uniprot.org/citations/33615517 | http://purl.uniprot.org/core/author | "Lu J."xsd:string |
| http://purl.uniprot.org/citations/33615517 | http://purl.uniprot.org/core/author | "Khan S."xsd:string |
| http://purl.uniprot.org/citations/33615517 | http://purl.uniprot.org/core/author | "Lu Q."xsd:string |
| http://purl.uniprot.org/citations/33615517 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/33615517 | http://purl.uniprot.org/core/author | "Tian J."xsd:string |
| http://purl.uniprot.org/citations/33615517 | http://purl.uniprot.org/core/author | "Wang Q."xsd:string |
| http://purl.uniprot.org/citations/33615517 | http://purl.uniprot.org/core/author | "Wu L."xsd:string |
| http://purl.uniprot.org/citations/33615517 | http://purl.uniprot.org/core/author | "Yan Q."xsd:string |
| http://purl.uniprot.org/citations/33615517 | http://purl.uniprot.org/core/author | "Zhang D."xsd:string |
| http://purl.uniprot.org/citations/33615517 | http://purl.uniprot.org/core/author | "Fang D."xsd:string |
| http://purl.uniprot.org/citations/33615517 | http://purl.uniprot.org/core/author | "Bosenberg M."xsd:string |
| http://purl.uniprot.org/citations/33615517 | http://purl.uniprot.org/core/author | "Muzumdar M.D."xsd:string |
| http://purl.uniprot.org/citations/33615517 | http://purl.uniprot.org/core/author | "Kurbatov V."xsd:string |
| http://purl.uniprot.org/citations/33615517 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33615517 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/33615517 | http://purl.uniprot.org/core/pages | "e106065"xsd:string |
| http://purl.uniprot.org/citations/33615517 | http://purl.uniprot.org/core/title | "5-Fluorouracil efficacy requires anti-tumor immunity triggered by cancer-cell-intrinsic STING."xsd:string |
| http://purl.uniprot.org/citations/33615517 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/33615517 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33615517 |
| http://purl.uniprot.org/citations/33615517 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33615517 |
| http://purl.uniprot.org/uniprot/#_A0A125R9I3-mappedCitation-33615517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33615517 |
| http://purl.uniprot.org/uniprot/#_D3Z5R0-mappedCitation-33615517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33615517 |