| http://purl.uniprot.org/citations/33621853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33621853 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factor c-Myb can be involved in the activation of many genes with protumorigenic function; however, its role in breast cancer (BC) development is still under discussion. c-Myb is considered as a tumor-promoting factor in the early phases of BC, on the other hand, its expression in BC patients relates to a good prognosis. Previously, we have shown that c-Myb controls the capacity of BC cells to form spontaneous lung metastasis. Reduced seeding of BC cells to the lungs is linked to high expression of c-Myb and a decline in expression of a specific set of inflammatory genes. Here, we unraveled a c-Myb-IL1α-NF-κB signaling axis that takes place in tumor cells. We report that an overexpression of c-Myb interfered with the activity of NF-κB in several BC cell lines. We identified IL1α to be essential for this interference since it was abrogated in the IL1α-deficient cells. Overexpression of IL1α, as well as addition of recombinant IL1α protein, activated NF-κB signaling and restored expression of the inflammatory signature genes suppressed by c-Myb. The endogenous levels of c-Myb negatively correlated with IL1α on both transcriptional and protein levels across BC cell lines. We concluded that inhibition of IL1α expression by c-Myb reduces NF-κB activity and disconnects the inflammatory circuit, a potentially targetable mechanism to mimic the antimetastatic effect of c-Myb with therapeutic perspective."xsd:string |
| http://purl.uniprot.org/citations/33621853 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neo.2021.01.002"xsd:string |
| http://purl.uniprot.org/citations/33621853 | http://purl.uniprot.org/core/author | "Smarda J."xsd:string |
| http://purl.uniprot.org/citations/33621853 | http://purl.uniprot.org/core/author | "Borsig L."xsd:string |
| http://purl.uniprot.org/citations/33621853 | http://purl.uniprot.org/core/author | "Benes P."xsd:string |
| http://purl.uniprot.org/citations/33621853 | http://purl.uniprot.org/core/author | "Knopfova L."xsd:string |
| http://purl.uniprot.org/citations/33621853 | http://purl.uniprot.org/core/author | "Trcka F."xsd:string |
| http://purl.uniprot.org/citations/33621853 | http://purl.uniprot.org/core/author | "Biglieri E."xsd:string |
| http://purl.uniprot.org/citations/33621853 | http://purl.uniprot.org/core/author | "Ducka M."xsd:string |
| http://purl.uniprot.org/citations/33621853 | http://purl.uniprot.org/core/author | "Cervinka J."xsd:string |
| http://purl.uniprot.org/citations/33621853 | http://purl.uniprot.org/core/author | "Kucerikova M."xsd:string |
| http://purl.uniprot.org/citations/33621853 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33621853 | http://purl.uniprot.org/core/name | "Neoplasia"xsd:string |
| http://purl.uniprot.org/citations/33621853 | http://purl.uniprot.org/core/pages | "326-336"xsd:string |
| http://purl.uniprot.org/citations/33621853 | http://purl.uniprot.org/core/title | "c-Myb interferes with inflammatory IL1alpha-NF-kappaB pathway in breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/33621853 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/33621853 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33621853 |
| http://purl.uniprot.org/citations/33621853 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33621853 |
| http://purl.uniprot.org/uniprot/#_A0A087WP26-mappedCitation-33621853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33621853 |
| http://purl.uniprot.org/uniprot/#_A0A087WPE1-mappedCitation-33621853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33621853 |
| http://purl.uniprot.org/uniprot/#_A0A087WPK5-mappedCitation-33621853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33621853 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DG19-mappedCitation-33621853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33621853 |
| http://purl.uniprot.org/uniprot/#_P11087-mappedCitation-33621853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33621853 |
| http://purl.uniprot.org/uniprot/#_A0A158SIS7-mappedCitation-33621853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33621853 |