| http://purl.uniprot.org/citations/33623790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33623790 | http://www.w3.org/2000/01/rdf-schema#comment | "Gastric cancer is one of the most prevalent human cancers with poor prognosis. Trastuzumab is a well-used targeted drug for gastric cancer with HER2 amplification. Trastuzumab resistance restrains the clinical use of trastuzumab. In this study, we reported human Gse1 coiled-coil protein (GSE1) promoted trastuzumab resistance in HER2-positive gastric cancer cells. Acquired trastuzumab-resistant gastric cancer cells overexpressed GSE1, and depletion of GSE1 decreased the trastuzumab resistance of trastuzumab-resistant gastric cancer cells. BCL-2 was a downstream gene positively regulated by GSE1 and also performed promoting the role of trastuzumab resistance in HER2-positive gastric cancer cells. A high level of GSE1 was associated with a high risk of tumor lymph node metastasis and higher clinical stage in HER2-positive gastric cancer patients. GSE1 was a potential target that could be used for HER2-positive gastric cancer therapy."xsd:string |
| http://purl.uniprot.org/citations/33623790 | http://purl.org/dc/terms/identifier | "doi:10.1155/2021/8834923"xsd:string |
| http://purl.uniprot.org/citations/33623790 | http://purl.uniprot.org/core/author | "Huang L."xsd:string |
| http://purl.uniprot.org/citations/33623790 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/33623790 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/33623790 | http://purl.uniprot.org/core/author | "Yuan X."xsd:string |
| http://purl.uniprot.org/citations/33623790 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/33623790 | http://purl.uniprot.org/core/author | "Xu A.M."xsd:string |
| http://purl.uniprot.org/citations/33623790 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33623790 | http://purl.uniprot.org/core/name | "Biomed Res Int"xsd:string |
| http://purl.uniprot.org/citations/33623790 | http://purl.uniprot.org/core/pages | "8834923"xsd:string |
| http://purl.uniprot.org/citations/33623790 | http://purl.uniprot.org/core/title | "Overexpression of GSE1 Related to Trastuzumab Resistance in Gastric Cancer Cells."xsd:string |
| http://purl.uniprot.org/citations/33623790 | http://purl.uniprot.org/core/volume | "2021"xsd:string |
| http://purl.uniprot.org/citations/33623790 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33623790 |
| http://purl.uniprot.org/citations/33623790 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33623790 |
| http://purl.uniprot.org/uniprot/#_B3KXH7-mappedCitation-33623790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33623790 |
| http://purl.uniprot.org/uniprot/#_Q14687-mappedCitation-33623790 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33623790 |
| http://purl.uniprot.org/uniprot/Q14687 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33623790 |
| http://purl.uniprot.org/uniprot/B3KXH7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33623790 |