| http://purl.uniprot.org/citations/33633734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33633734 | http://www.w3.org/2000/01/rdf-schema#comment | "Hematopoietic stem cell transplantation (HSCT) is a curative therapy for patients with malignant hematologic diseases. Killer immunoglobin-like receptor (KIR) expressed by NK cells is closely associated with the transplant outcomes, and it has been widely explored and debated for a few decades. Recently published studies have revealed that inhibitory KIRs (iKIRs) are educated by their cognate human lymphocyte antigen (HLA) ligands, and that decreased iKIR-HLA pairs post-transplantation may indicate a reduced NK cell function and impaired control of the primary disease. However, this theory still needs to be validated by additional clinical studies. Here we conducted a retrospective analysis of 246 patients who received haploidentical (haplo)-HSCT at our treatment center between January 2015 and June 2018. Our data suggests that decreased iKIR-HLA C pair post-HSCT correlated with a significantly higher risk of relapse [hazard risk (HR) = 2.95, p = 0.019] and reduced overall survival (OS) (HR = 3.74, p = 0.001) and disease-free survival (DFS) (HR = 4.05, p = 0.0004) in patients with myeloid disease. In conclusion, decreased iKIR-HLA C pair should be avoided during anti-thymocyte globulin (ATG)-based haplo-HSCT, especially for patients with myeloid disease."xsd:string |
| http://purl.uniprot.org/citations/33633734 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2020.614488"xsd:string |
| http://purl.uniprot.org/citations/33633734 | http://purl.uniprot.org/core/author | "Huang H."xsd:string |
| http://purl.uniprot.org/citations/33633734 | http://purl.uniprot.org/core/author | "Gao F."xsd:string |
| http://purl.uniprot.org/citations/33633734 | http://purl.uniprot.org/core/author | "Lai X."xsd:string |
| http://purl.uniprot.org/citations/33633734 | http://purl.uniprot.org/core/author | "Luo Y."xsd:string |
| http://purl.uniprot.org/citations/33633734 | http://purl.uniprot.org/core/author | "Shi J."xsd:string |
| http://purl.uniprot.org/citations/33633734 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/33633734 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/33633734 | http://purl.uniprot.org/core/author | "Tan Y."xsd:string |
| http://purl.uniprot.org/citations/33633734 | http://purl.uniprot.org/core/author | "Yu J."xsd:string |
| http://purl.uniprot.org/citations/33633734 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/33633734 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/33633734 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33633734 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/33633734 | http://purl.uniprot.org/core/pages | "614488"xsd:string |
| http://purl.uniprot.org/citations/33633734 | http://purl.uniprot.org/core/title | "Decreased iKIR-HLA C Pair Confers Worse Clinical Outcomes for Patients With Myeloid Disease Receiving Antithymocyte Globulin-Based Haploidentical Hematopoietic Stem Cell Transplantation."xsd:string |
| http://purl.uniprot.org/citations/33633734 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/33633734 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33633734 |
| http://purl.uniprot.org/citations/33633734 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33633734 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C549-mappedCitation-33633734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33633734 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C553-mappedCitation-33633734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33633734 |
| http://purl.uniprot.org/uniprot/#_A0A089N0V0-mappedCitation-33633734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33633734 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C850-mappedCitation-33633734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33633734 |