| http://purl.uniprot.org/citations/33634895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33634895 | http://www.w3.org/2000/01/rdf-schema#comment | "The BRCA2 tumor suppressor is a DNA double-strand break (DSB) repair factor essential for maintaining genome integrity. BRCA2-deficient cells spontaneously accumulate DNA-RNA hybrids, a known source of genome instability. However, the specific role of BRCA2 on these structures remains poorly understood. Here we identified the DEAD-box RNA helicase DDX5 as a BRCA2-interacting protein. DDX5 associates with DNA-RNA hybrids that form in the vicinity of DSBs, and this association is enhanced by BRCA2. Notably, BRCA2 stimulates the DNA-RNA hybrid-unwinding activity of DDX5 helicase. An impaired BRCA2-DDX5 interaction, as observed in cells expressing the breast cancer variant BRCA2-T207A, reduces the association of DDX5 with DNA-RNA hybrids, decreases the number of RPA foci, and alters the kinetics of appearance of RAD51 foci upon irradiation. Our findings are consistent with DNA-RNA hybrids constituting an impediment for the repair of DSBs by homologous recombination and reveal BRCA2 and DDX5 as active players in their removal."xsd:string |
| http://purl.uniprot.org/citations/33634895 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.2020106018"xsd:string |
| http://purl.uniprot.org/citations/33634895 | http://purl.uniprot.org/core/author | "Martin C."xsd:string |
| http://purl.uniprot.org/citations/33634895 | http://purl.uniprot.org/core/author | "Barroso S."xsd:string |
| http://purl.uniprot.org/citations/33634895 | http://purl.uniprot.org/core/author | "Silva S."xsd:string |
| http://purl.uniprot.org/citations/33634895 | http://purl.uniprot.org/core/author | "Martinez J.S."xsd:string |
| http://purl.uniprot.org/citations/33634895 | http://purl.uniprot.org/core/author | "Ehlen A."xsd:string |
| http://purl.uniprot.org/citations/33634895 | http://purl.uniprot.org/core/author | "Sessa G."xsd:string |
| http://purl.uniprot.org/citations/33634895 | http://purl.uniprot.org/core/author | "Aguilera A."xsd:string |
| http://purl.uniprot.org/citations/33634895 | http://purl.uniprot.org/core/author | "Loew D."xsd:string |
| http://purl.uniprot.org/citations/33634895 | http://purl.uniprot.org/core/author | "Lombard B."xsd:string |
| http://purl.uniprot.org/citations/33634895 | http://purl.uniprot.org/core/author | "Carreira A."xsd:string |
| http://purl.uniprot.org/citations/33634895 | http://purl.uniprot.org/core/author | "Vagner S."xsd:string |
| http://purl.uniprot.org/citations/33634895 | http://purl.uniprot.org/core/author | "Gomez-Gonzalez B."xsd:string |
| http://purl.uniprot.org/citations/33634895 | http://purl.uniprot.org/core/author | "Martineau S."xsd:string |
| http://purl.uniprot.org/citations/33634895 | http://purl.uniprot.org/core/author | "Perez-Calero C."xsd:string |
| http://purl.uniprot.org/citations/33634895 | http://purl.uniprot.org/core/author | "Beaurepere R."xsd:string |
| http://purl.uniprot.org/citations/33634895 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33634895 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/33634895 | http://purl.uniprot.org/core/pages | "e106018"xsd:string |
| http://purl.uniprot.org/citations/33634895 | http://purl.uniprot.org/core/title | "BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair‡."xsd:string |
| http://purl.uniprot.org/citations/33634895 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/33634895 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33634895 |
| http://purl.uniprot.org/citations/33634895 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33634895 |