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http://purl.uniprot.org/citations/33636223http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/33636223http://www.w3.org/2000/01/rdf-schema#comment"

Background

Reduction in L-type Ca2+ current (ICa,L) density is a hallmark of the electrical remodeling in atrial fibrillation (AF). The expression of miR-155, whose predicted target gene is the α1c subunit of the calcium channel (CACNA1C), was upregulated in atrial cardiomyocytes (aCMs) from patients with paroxysmal AF.The study is to determine miR-155 could target the gene expression of ICa,L and contribute to electrical remodeling in AF.

Methods

The expression of miR-155 and CACNA1C was assessed in aCMs from patients with paroxysmal AF and healthy control. ICa,L properties were observed after miR-155 transfection in human induced pluripotent stem cell derived atrial cardiomyocytes (hiPSC-aCMs). Furthermore, an miR-155 transgene (Tg) and knock-out (KO) mouse model was generated to determine whether miR-155 was involved in ICa,L-related electrical remodeling in AF by targeting CACNA1C.

Results

The expression level of miR-155 was increased, while the expression level of CACNA1C reduced in the aCMs of patients with AF. miR-155 transfection in hiPSC-aCMs produced changes in ICa,L properties qualitatively similar to those produced by AF. miR-155/Tg mice developed a shortened action potential duration and increased vulnerability to AF, which was associated with decreased ICa,L and attenuated by an miR-155 inhibitor. Finally, the genetic inhibition of miR-155 prevented AF induction in miR-155/KO mice with no changes in ICa,L properties.

Conclusions

The increased miR-155 expression in aCMs was sufficient for the reduction in the density of ICa,L and the underlying electronic remodeling. The inhibition of miR-155 prevented ICa,L-related electric remodeling in AF and might constitute a novel anti-AF approach targeting electrical remodeling."xsd:string
http://purl.uniprot.org/citations/33636223http://purl.org/dc/terms/identifier"doi:10.1016/j.yjmcc.2021.02.008"xsd:string
http://purl.uniprot.org/citations/33636223http://purl.uniprot.org/core/author"Chen P."xsd:string
http://purl.uniprot.org/citations/33636223http://purl.uniprot.org/core/author"Liu Q."xsd:string
http://purl.uniprot.org/citations/33636223http://purl.uniprot.org/core/author"Liu Y."xsd:string
http://purl.uniprot.org/citations/33636223http://purl.uniprot.org/core/author"Ma X."xsd:string
http://purl.uniprot.org/citations/33636223http://purl.uniprot.org/core/author"Ma Y."xsd:string
http://purl.uniprot.org/citations/33636223http://purl.uniprot.org/core/author"Wang J."xsd:string
http://purl.uniprot.org/citations/33636223http://purl.uniprot.org/core/author"Zeng C."xsd:string
http://purl.uniprot.org/citations/33636223http://purl.uniprot.org/core/author"Zhao C."xsd:string
http://purl.uniprot.org/citations/33636223http://purl.uniprot.org/core/author"Zhao Y."xsd:string
http://purl.uniprot.org/citations/33636223http://purl.uniprot.org/core/author"Yao Y."xsd:string
http://purl.uniprot.org/citations/33636223http://purl.uniprot.org/core/author"Ye Q."xsd:string
http://purl.uniprot.org/citations/33636223http://purl.uniprot.org/core/author"Bai C."xsd:string
http://purl.uniprot.org/citations/33636223http://purl.uniprot.org/core/author"Bai S."xsd:string
http://purl.uniprot.org/citations/33636223http://purl.uniprot.org/core/author"Xin M."xsd:string
http://purl.uniprot.org/citations/33636223http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/33636223http://purl.uniprot.org/core/name"J Mol Cell Cardiol"xsd:string
http://purl.uniprot.org/citations/33636223http://purl.uniprot.org/core/pages"58-65"xsd:string
http://purl.uniprot.org/citations/33636223http://purl.uniprot.org/core/title"Inhibiting microRNA-155 attenuates atrial fibrillation by targeting CACNA1C."xsd:string
http://purl.uniprot.org/citations/33636223http://purl.uniprot.org/core/volume"155"xsd:string
http://purl.uniprot.org/citations/33636223http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/33636223
http://purl.uniprot.org/citations/33636223http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/33636223
http://purl.uniprot.org/uniprot/#_A0A0A0MR67-mappedCitation-33636223http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/33636223
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