| http://purl.uniprot.org/citations/33646123 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33646123 | http://www.w3.org/2000/01/rdf-schema#comment | "Neural circuit assembly in the brain requires precise establishment of synaptic connections, but the mechanisms of synapse assembly remain incompletely understood. Latrophilins are postsynaptic adhesion-GPCRs that engage in trans-synaptic complexes with presynaptic teneurins and FLRTs. In mouse CA1-region neurons, Latrophilin-2 and Latrophilin-3 are essential for formation of entorhinal-cortex-derived and Schaffer-collateral-derived synapses, respectively. However, it is unknown whether latrophilins function as GPCRs in synapse formation. Here, we show that Latrophilin-2 and Latrophilin-3 exhibit constitutive GPCR activity that increases cAMP levels, which was blocked by a mutation interfering with G-protein and arrestin interactions of GPCRs. The same mutation impaired the ability of Latrophilin-2 and Latrophilin-3 to rescue the synapse-loss phenotype in Latrophilin-2 and Latrophilin-3 knockout neurons in vivo. Our results suggest that Latrophilin-2 and Latrophilin-3 require GPCR signaling in synapse formation, indicating that latrophilins promote synapse formation in the hippocampus by activating a classical GPCR-signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/33646123 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.65717"xsd:string |
| http://purl.uniprot.org/citations/33646123 | http://purl.uniprot.org/core/author | "Sudhof T.C."xsd:string |
| http://purl.uniprot.org/citations/33646123 | http://purl.uniprot.org/core/author | "Sando R."xsd:string |
| http://purl.uniprot.org/citations/33646123 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33646123 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/33646123 | http://purl.uniprot.org/core/pages | "e65717"xsd:string |
| http://purl.uniprot.org/citations/33646123 | http://purl.uniprot.org/core/title | "Latrophilin GPCR signaling mediates synapse formation."xsd:string |
| http://purl.uniprot.org/citations/33646123 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/33646123 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33646123 |
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| http://purl.uniprot.org/uniprot/#_A0A0G2JDF4-mappedCitation-33646123 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33646123 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDH6-mappedCitation-33646123 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33646123 |
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| http://purl.uniprot.org/uniprot/#_A0A0G2JDU4-mappedCitation-33646123 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33646123 |
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| http://purl.uniprot.org/uniprot/#_A0A0G2JGZ4-mappedCitation-33646123 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33646123 |
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| http://purl.uniprot.org/uniprot/#_A0A0G2JEQ8-mappedCitation-33646123 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33646123 |
| http://purl.uniprot.org/uniprot/#_D3YVT9-mappedCitation-33646123 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33646123 |