| http://purl.uniprot.org/citations/33646271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33646271 | http://www.w3.org/2000/01/rdf-schema#comment | "Cdc42-GTP is required for apical domain formation in epithelial cells, where it recruits and activates the Par-6-aPKC polarity complex, but how the activity of Cdc42 itself is restricted apically is unclear. We used sequence analysis and 3D structural modeling to determine which Drosophila GTPase-activating proteins (GAPs) are likely to interact with Cdc42 and identified RhoGAP19D as the only high-probability Cdc42GAP required for polarity in the follicular epithelium. RhoGAP19D is recruited by α-catenin to lateral E-cadherin adhesion complexes, resulting in exclusion of active Cdc42 from the lateral domain. rhogap19d mutants therefore lead to lateral Cdc42 activity, which expands the apical domain through increased Par-6/aPKC activity and stimulates lateral contractility through the myosin light chain kinase, Genghis khan (MRCK). This causes buckling of the epithelium and invasion into the adjacent tissue, a phenotype resembling that of precancerous breast lesions. Thus, RhoGAP19D couples lateral cadherin adhesion to the apical localization of active Cdc42, thereby suppressing epithelial invasion."xsd:string |
| http://purl.uniprot.org/citations/33646271 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.202009116"xsd:string |
| http://purl.uniprot.org/citations/33646271 | http://purl.uniprot.org/core/author | "Inoue Y."xsd:string |
| http://purl.uniprot.org/citations/33646271 | http://purl.uniprot.org/core/author | "Russell R.B."xsd:string |
| http://purl.uniprot.org/citations/33646271 | http://purl.uniprot.org/core/author | "St Johnston D."xsd:string |
| http://purl.uniprot.org/citations/33646271 | http://purl.uniprot.org/core/author | "Gallop J.L."xsd:string |
| http://purl.uniprot.org/citations/33646271 | http://purl.uniprot.org/core/author | "Raimondi F."xsd:string |
| http://purl.uniprot.org/citations/33646271 | http://purl.uniprot.org/core/author | "Bastock R."xsd:string |
| http://purl.uniprot.org/citations/33646271 | http://purl.uniprot.org/core/author | "Fic W."xsd:string |
| http://purl.uniprot.org/citations/33646271 | http://purl.uniprot.org/core/author | "Los E."xsd:string |
| http://purl.uniprot.org/citations/33646271 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33646271 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/33646271 | http://purl.uniprot.org/core/pages | "e202009116"xsd:string |
| http://purl.uniprot.org/citations/33646271 | http://purl.uniprot.org/core/title | "RhoGAP19D inhibits Cdc42 laterally to control epithelial cell shape and prevent invasion."xsd:string |
| http://purl.uniprot.org/citations/33646271 | http://purl.uniprot.org/core/volume | "220"xsd:string |
| http://purl.uniprot.org/citations/33646271 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33646271 |
| http://purl.uniprot.org/citations/33646271 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33646271 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFQ6-mappedCitation-33646271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33646271 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KG15-mappedCitation-33646271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33646271 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHN3-mappedCitation-33646271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33646271 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHS1-mappedCitation-33646271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33646271 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHY2-mappedCitation-33646271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33646271 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEQ8-mappedCitation-33646271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33646271 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEV2-mappedCitation-33646271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33646271 |