| http://purl.uniprot.org/citations/33647291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33647291 | http://www.w3.org/2000/01/rdf-schema#comment | "Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) form heterodimers that activate target gene transcription by recruiting co-activator complexes in response to ligand binding. The nuclear receptor (NR) co-activator TIF2 mediates this recruitment by interacting with the ligand-binding domain (LBD) of NRs trough the nuclear receptor interaction domain (TIF2NRID) containing three highly conserved α-helical LxxLL motifs (NR-boxes). The precise binding mode of this domain to RXR/RAR is not clear due to the disordered nature of TIF2. Here we present the structural characterization of TIF2NRID by integrating several experimental (NMR, SAXS, Far-UV CD, SEC-MALS) and computational data. Collectively, the data are in agreement with a largely disordered protein with partially structured regions, including the NR-boxes and their flanking regions, which are evolutionary conserved. NMR and X-ray crystallographic data on TIF2NRID in complex with RXR/RAR reveal a multisite binding of the three NR-boxes as well as an active role of their flanking regions in the interaction."xsd:string |
| http://purl.uniprot.org/citations/33647291 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jmb.2021.166899"xsd:string |
| http://purl.uniprot.org/citations/33647291 | http://purl.uniprot.org/core/author | "Allemand F."xsd:string |
| http://purl.uniprot.org/citations/33647291 | http://purl.uniprot.org/core/author | "Schubert M."xsd:string |
| http://purl.uniprot.org/citations/33647291 | http://purl.uniprot.org/core/author | "Sibille N."xsd:string |
| http://purl.uniprot.org/citations/33647291 | http://purl.uniprot.org/core/author | "Bourguet W."xsd:string |
| http://purl.uniprot.org/citations/33647291 | http://purl.uniprot.org/core/author | "Bernado P."xsd:string |
| http://purl.uniprot.org/citations/33647291 | http://purl.uniprot.org/core/author | "Carvalho J.E."xsd:string |
| http://purl.uniprot.org/citations/33647291 | http://purl.uniprot.org/core/author | "le Maire A."xsd:string |
| http://purl.uniprot.org/citations/33647291 | http://purl.uniprot.org/core/author | "Germain P."xsd:string |
| http://purl.uniprot.org/citations/33647291 | http://purl.uniprot.org/core/author | "Senicourt L."xsd:string |
| http://purl.uniprot.org/citations/33647291 | http://purl.uniprot.org/core/author | "Guee L."xsd:string |
| http://purl.uniprot.org/citations/33647291 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33647291 | http://purl.uniprot.org/core/name | "J Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/33647291 | http://purl.uniprot.org/core/pages | "166899"xsd:string |
| http://purl.uniprot.org/citations/33647291 | http://purl.uniprot.org/core/title | "Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR)."xsd:string |
| http://purl.uniprot.org/citations/33647291 | http://purl.uniprot.org/core/volume | "433"xsd:string |
| http://purl.uniprot.org/citations/33647291 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33647291 |
| http://purl.uniprot.org/citations/33647291 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33647291 |
| http://purl.uniprot.org/uniprot/#_P10276-mappedCitation-33647291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33647291 |
| http://purl.uniprot.org/uniprot/#_Q15596-mappedCitation-33647291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33647291 |
| http://purl.uniprot.org/uniprot/#_A0A0B6XJZ8-mappedCitation-33647291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33647291 |
| http://purl.uniprot.org/uniprot/#_A3FFT2-mappedCitation-33647291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33647291 |
| http://purl.uniprot.org/uniprot/#_A2AJP1-mappedCitation-33647291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33647291 |